Synthesis and Biological Evaluation of an Indomethacin Library Reveals a New Class of Angiogenesis??Related Kinase Inhibitors

…, P Baumhof, R Mazitschek, O Müller…

Index: Rosenbaum, Claudia; Baumhof, Patrick; Mazitschek, Ralf; Mueller, Oliver; Giannis, Athanassios; Waldmann, Herbert Angewandte Chemie - International Edition, 2004 , vol. 43, # 2 p. 224 - 228

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Citation Number: 52

Abstract

It has been demonstrated that indomethacin induces G1 arrest and apoptosis of human colorectal cancer cells by influencing the Wnt signaling pathway,[10] downregulates the transcriptional activity of the peroxisome proliferation-activated receptor δ,[11] and inhibits ...