One-pot synthesis of simple alkaloids: 2, 3-polymethylene-4 (3H)-quinazolinones, luotonin A, tryptanthrin, and rutaecarpine

KC Jahng, SI Kim, DH Kim, CS Seo, JK Son…

Index: Jahng, Katherine Chae; Kim, Seung Ill; Kim, Dong Hyeon; Seo, Chang Seob; Son, Jong-Keun; Lee, Seung Ho; Lee, Eung Seok; Jahng, Yurngdong Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 607 - 609

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Citation Number: 46

Abstract

One-pot synthesis of various 2, 3-polymethylene-4 (3H)-quinazolinones from anthranilic acid, corresponding lactam and SOCl 2 is described, which can be applicable to the synthesis of simple 4 (3H)-quinazolinone-derived alkaloids, such as luotonin A, tryptanthrin, and rutaecarpine.