Manganese??Catalyzed Oxidative Cross??Coupling of Grignard Reagents with Oxygen as an Oxidant

G Cahiez, C Duplais, J Buendia

Index: Cahiez, Gerard; Duplais, Christophe; Buendia, Julien Angewandte Chemie, International Edition, 2009 , vol. 48, # 36 p. 6731 - 6734

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Citation Number: 42

Abstract

Until now, only rare examples of oxidative cross-coupling reactions have been described.[1– 4] Lipshutz et al.[1] and, more recently, Knochel et al.[2] showed that, at low temperature, oxidation of mixed organocuprates RR'CuLi gives the heterocoupling product RÀR'in good yield. Both reactions use a stoichiometric amount of copper. Two metal-catalyzed procedures were also reported. Lei et al.[3] coupled an alkyl zinc with an alkynyl stannane ...