ChemBioChem 2012-09-24

Rates of fatty acid oxidations by P450 compound I are pH dependent.

Zhi Su, John H Horner, Martin Newcomb

Index: ChemBioChem. 13(14) , 2061-4, (2012)

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Abstract

The rates of oxidation of fatty acids by CYP119 compound I were dependent on the pH of the medium. The plot shows log k values for reactions of acids as a function of pH, where the slopes indicate mixed third-order and fourth-order dependence on base concentration. For palmitic acid, the rate increased 50-fold over the pH range 6.8-7.3.Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.