e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

2-, 3-, and 4-(. alpha.,. alpha.,. beta.,. beta.-Tetrafluorophenethyl) benzylamines. A new class of antiarrhythmic agents

…, JB Wong, EL Engelhardt, ML Torchiana…

Index: Christy; Colton; Mackay; Staas; Wong; Engelhardt; Torchiana; Stone Journal of Medicinal Chemistry, 1977 , vol. 20, # 3 p. 421 - 430

Full Text: HTML

Citation Number: 13

Abstract

28 also was obtained from the acid 20 via the Curtius reaction and hydrolysis of the urethane 25 to the aniline 26. Preparation of a bis (benzy1amine) derivative in the ortho- substituted series from the 2, 2'-dibromide 2i failed when 2i proved to be resistant to reaction with CuCN. Alternatively, the 2, 2'-dimethyl compound 2g was dibrominated successfully with NBS and the bis (benzy1 bromide) 27 underwent the Delepine reaction to afford the ...

Benzyl chloride Structure

Benzyl chloride

~%

4-BroMobenzil Structure

3-Bromobenzonitrile Structure

3-Bromobenzonitrile

Benzyl chloride Structure

Benzyl chloride

~%

1-(3-bromophenyl)-2-phenylethanone Structure

1-(3-bromopheny...

4-BroMobenzil Structure

~%

1-bromo-4-(1,1,2,2-tetrafluoro-2-phenylethyl)benzene Structure

1-bromo-4-(1,1,...

1-(4-Bromophenyl)-2-phenylethanone Structure

1-(4-Bromopheny...

~%

1-bromo-4-(1,1,2,2-tetrafluoro-2-phenylethyl)benzene Structure

1-bromo-4-(1,1,...

Benzyl chloride Structure

Benzyl chloride

~%

1-bromo-4-(1,1,2,2-tetrafluoro-2-phenylethyl)benzene Structure

1-bromo-4-(1,1,...

2-(4-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl)propan-2-ol Structure

2-(4-(1,1,2,2-t...

~%

1-prop-1-en-2-yl-4-(1,1,2,2-tetrafluoro-2-phenylethyl)benzene Structure

1-prop-1-en-2-y...

4-BroMobenzil Structure

~%

1-prop-1-en-2-yl-4-(1,1,2,2-tetrafluoro-2-phenylethyl)benzene Structure

1-prop-1-en-2-y...

1-(4-Bromophenyl)-2-phenylethanone Structure

1-(4-Bromopheny...

~%

1-prop-1-en-2-yl-4-(1,1,2,2-tetrafluoro-2-phenylethyl)benzene Structure

1-prop-1-en-2-y...

Benzyl chloride Structure

Benzyl chloride

~%

1-prop-1-en-2-yl-4-(1,1,2,2-tetrafluoro-2-phenylethyl)benzene Structure

1-prop-1-en-2-y...

4-BroMobenzil Structure

~%

1-[4-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]ethanone Structure

1-[4-(1,1,2,2-t...

1-(4-Bromophenyl)-2-phenylethanone Structure

1-(4-Bromopheny...

~%

1-[4-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]ethanone Structure

1-[4-(1,1,2,2-t...

1-bromo-4-(1,1,2,2-tetrafluoro-2-phenylethyl)benzene Structure

1-bromo-4-(1,1,...

~%

1-[4-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]ethanone Structure

1-[4-(1,1,2,2-t...

Benzyl chloride Structure

Benzyl chloride

~%

1-[4-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]ethanone Structure

1-[4-(1,1,2,2-t...

N/A Structure

METHYLMAGNESIUM BROMIDE Structure

METHYLMAGNESIUM...

~%

1-[4-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]ethanone Structure

1-[4-(1,1,2,2-t...

1-[2-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]ethanone Structure

1-[2-(1,1,2,2-t...

~%

N-[1-[2-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]ethylidene]hydroxylamine Structure

N-[1-[2-(1,1,2,...

2-Bromobenzonitrile Structure

2-Bromobenzonitrile

4-Fluorobenzyl chloride Structure

4-Fluorobenzyl ...

~%

2'-BROMO-2-(4-FLUOROPHENYL)ACETOPHENONE Structure

2'-BROMO-2-(4-F...

Ethanedione, bis(2-bromophenyl)- Structure

Ethanedione, bi...

~%

1-bromo-2-[2-(2-bromophenyl)-1,1,2,2-tetrafluoroethyl]benzene Structure

1-bromo-2-[2-(2...

2-Bromobenzaldehyde Structure

2-Bromobenzaldehyde

~%

1-bromo-2-[2-(2-bromophenyl)-1,1,2,2-tetrafluoroethyl]benzene Structure

1-bromo-2-[2-(2...

2-Bromo-4-fluorobenzonitrile Structure

2-Bromo-4-fluor...

~%

5-fluoro-2-(1,1,2,2-tetrafluoro-2-phenylethyl)benzonitrile Structure

5-fluoro-2-(1,1...

2'-Brom-4'-fluor-2-phenylacetophenon Structure

2'-Brom-4'-fluo...

~%

5-fluoro-2-(1,1,2,2-tetrafluoro-2-phenylethyl)benzonitrile Structure

5-fluoro-2-(1,1...

2-Brom-4-fluor-benzil Structure

2-Brom-4-fluor-...

~%

5-fluoro-2-(1,1,2,2-tetrafluoro-2-phenylethyl)benzonitrile Structure

5-fluoro-2-(1,1...

Benzyl chloride Structure

Benzyl chloride

~%

5-fluoro-2-(1,1,2,2-tetrafluoro-2-phenylethyl)benzonitrile Structure

5-fluoro-2-(1,1...

2-bromo-4,α,α,α',α'-pentafluorobibenzyl Structure

2-bromo-4,α,α,α...

Copper cyanide Structure

~%

5-fluoro-2-(1,1,2,2-tetrafluoro-2-phenylethyl)benzonitrile Structure

5-fluoro-2-(1,1...

2-Bromobenzonitrile Structure

2-Bromobenzonitrile

~%

1,3-bis[2-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]urea Structure

1,3-bis[2-(1,1,...

Benzyl chloride Structure

Benzyl chloride

~%

1,3-bis[2-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]urea Structure

1,3-bis[2-(1,1,...

1-(2-BROMOETHYL)PYRROLE Structure

1-(2-BROMOETHYL...

~%

1,3-bis[2-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]urea Structure

1,3-bis[2-(1,1,...

2-Bromphenylbenzyl-ketimin Structure

2-Bromphenylben...

~%

1,3-bis[2-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]urea Structure

1,3-bis[2-(1,1,...

1-(2-bromophenyl)-2-phenylethane-1,2-dione Structure

1-(2-bromopheny...

~%

1,3-bis[2-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]urea Structure

1,3-bis[2-(1,1,...

N/A Structure

~%

1,3-bis[2-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]urea Structure

1,3-bis[2-(1,1,...

N/A Structure

~%

1,3-bis[2-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]urea Structure

1,3-bis[2-(1,1,...

5-fluoro-2-(1,1,2,2-tetrafluoro-2-phenylethyl)benzonitrile Structure

5-fluoro-2-(1,1...

~%

[5-fluoro-2-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]methanamine Structure

[5-fluoro-2-(1,...

2-Bromo-4-fluorobenzonitrile Structure

2-Bromo-4-fluor...

~%

[5-fluoro-2-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]methanamine Structure

[5-fluoro-2-(1,...

2'-Brom-4'-fluor-2-phenylacetophenon Structure

2'-Brom-4'-fluo...

~%

[5-fluoro-2-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]methanamine Structure

[5-fluoro-2-(1,...

2-Brom-4-fluor-benzil Structure

2-Brom-4-fluor-...

~%

[5-fluoro-2-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]methanamine Structure

[5-fluoro-2-(1,...

2-bromo-4,α,α,α',α'-pentafluorobibenzyl Structure

2-bromo-4,α,α,α...

~%

[5-fluoro-2-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]methanamine Structure

[5-fluoro-2-(1,...

Benzyl chloride Structure

Benzyl chloride

~%

[5-fluoro-2-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]methanamine Structure

[5-fluoro-2-(1,...

1-(3-bromophenyl)-2-phenylethanone Structure

1-(3-bromopheny...

~%

3-BroMobenzil Structure

3-Bromobenzonitrile Structure

3-Bromobenzonitrile

~%

3-BroMobenzil Structure

Benzyl chloride Structure

Benzyl chloride

~%

3-BroMobenzil Structure

2-Bromphenylbenzyl-ketimin Structure

2-Bromphenylben...

~%

1-(2-BROMOETHYL)PYRROLE Structure

1-(2-BROMOETHYL...

2-Bromobenzonitrile Structure

2-Bromobenzonitrile

~%

1-(2-BROMOETHYL)PYRROLE Structure

1-(2-BROMOETHYL...

Benzyl chloride Structure

Benzyl chloride

~%

1-(2-BROMOETHYL)PYRROLE Structure

1-(2-BROMOETHYL...

2-Bromobenzonitrile Structure

2-Bromobenzonitrile

Benzyl chloride Structure

Benzyl chloride

~%

1-(2-BROMOETHYL)PYRROLE Structure

1-(2-BROMOETHYL...

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