Tetrahedron

Microwave-assisted solvent-free intramolecular 1, 3-dipolar cycloaddition reactions leading to hexahydrochromeno [4, 3-b] pyrroles: scope and limitations

J Pospíšil, M Potáček

Index: Pospisil, Jiri; Potacek, Milan Tetrahedron, 2007 , vol. 63, # 2 p. 337 - 346

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Citation Number: 40

Abstract

We report the microwave-assisted solvent-free synthesis of hexahydrochromeno [4, 3-b] pyrroles. Intramolecular 1, 3-dipolar cycloadditions proceed under these conditions within 15–40min in 16–84% yields. An influence of the microwave irradiation upon various [3+ 2] cycloaddition reaction intermediates was studied. Additionally, a scope and limitations of these reactions including an influence of the dipolarophile geometry upon the ...