Steroids 2004-09-01

Synthesis of 3-methyl-3-hydroxy-6-oxo-androstane derivatives.

Hana Chodounská, Vladimír Pouzar, Milos Budesínský, Barbora Slavíková, Ladislav Kohout

Index: Steroids 69(10) , 605-12, (2004)

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Abstract

3alpha,17beta-Dihydroxy-3beta-methyl-5alpha-androstan-6-one (1) and 3beta,17beta-dihydroxy-3alpha-methyl-5alpha-androstan-6-one (13) were prepared by the reaction of methylmagnesium bromide with the 3-ketosteroids. Structures and configurations in position 3 were determined by NMR spectra. Substitution in the position 6 influences the ratio of the products.