Tetrahedron letters

A general method for the alkaline cleavage of enolisable ketones

A Žabjek, A Petrič

Index: Zabjek, Alenka; Petric, Andrej Tetrahedron Letters, 1999 , vol. 40, # 33 p. 6077 - 6078

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Citation Number: 23

Abstract

An efficient method is described for the cleavage of enolisable aryl methyl and aryl ethyl ketones using an excess of KOH in DMF at an elevated temperature. It presents a general hydrolytic method yielding aromatic carboxylic acids, and is complementary to the widely used oxidative methods for ketone cleavage.