Molecules 2010-01-01

Synthesis and biological activity of trans-tiliroside derivatives as potent anti-diabetic agents.

Yujin Zhu, Yanjun Zhang, Yi Liu, Hongwan Chu, Hongquan Duan

Index: Molecules 15(12) , 9174-83, (2010)

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Abstract

A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, 1H-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-tiliroside exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells compared with the positive control (metformin). This research provides useful clues for further design and discovery of anti-diabetic agents.