Zeitschrift fuer Naturforschung. Section C 2009-01-01

Bioactivity of flavonoids isolated from Lychnophora markgravii against Leishmania amazonensis amastigotes.

Marcos José Salvador, Fabiana Terezinha Sartori, Ana Claudia B C Sacilotto, Elizabeth M F Pral, Silvia Celina Alfieri, Walter Vichnewski

Index: Z. Naturforsch., C, J. Biosci. 64(7-8) , 509-12, (2009)

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Abstract

The bioactivity of the flavonoids pinostrobin (1), pinocembrin (2), tectochrysin (3), galangin 3-methyl ether (4), and tiliroside (5) isolated from Lychnophora markgravii aerial parts was investigated in vitro against amastigote stages of Leishmania amazonensis. The compounds were isolated by several chromatographic techniques and their chemical structures were established by ESI-MS and NMR spectroscopic data. The flavonoids 1 and 3 were the most active compounds; they markedly reduced the viability of Leishmania amastigotes.