Alogliptin benzoate
Modify Date: 2025-08-21 17:09:47
Alogliptin benzoate structure
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Common Name | Alogliptin benzoate | ||
|---|---|---|---|---|
| CAS Number | 850649-62-6 | Molecular Weight | 461.513 | |
| Density | N/A | Boiling Point | 671.2ºC at 760 mmHg | |
| Molecular Formula | C25H27N5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 359.7ºC | |
Use of Alogliptin benzoateAlogliptin benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.IC50 value: <10 nMTarget: DPP4Alogliptin is an orally administered, anti-diabetic drug in the DPP-4 inhibitor class. A randomized clinical trial reporting in 2011 aimed to determine the efficacy and safety of alogliptin versus placebo and voglibose among newly diagnosed Type 2 diabetes patients in Japan. The main outcome indicated that alogliptin was statistically superior to both comparitors. A randomized clinical trial reporting in 2012 aimed to demonstrate that alogliptin was "non-inferior" to a "very low fat/calorie traditional Japanese diet" among newly diagnosed Type 2 diabetes patients in Japan. The outcome indicated that both the drug and dietary treatments comparably impacted indicators of the diabetic condition, such as HbA1c levels and glycemic efficacy. The drug treatment had its impact without changing body mass index (BMI), but the dietary treatment was accompanied by a significant reduction in the BMI… |
| Name | alogliptin benzoate |
|---|---|
| Synonym | More Synonyms |
| Description | Alogliptin benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.IC50 value: <10 nMTarget: DPP4Alogliptin is an orally administered, anti-diabetic drug in the DPP-4 inhibitor class. A randomized clinical trial reporting in 2011 aimed to determine the efficacy and safety of alogliptin versus placebo and voglibose among newly diagnosed Type 2 diabetes patients in Japan. The main outcome indicated that alogliptin was statistically superior to both comparitors. A randomized clinical trial reporting in 2012 aimed to demonstrate that alogliptin was "non-inferior" to a "very low fat/calorie traditional Japanese diet" among newly diagnosed Type 2 diabetes patients in Japan. The outcome indicated that both the drug and dietary treatments comparably impacted indicators of the diabetic condition, such as HbA1c levels and glycemic efficacy. The drug treatment had its impact without changing body mass index (BMI), but the dietary treatment was accompanied by a significant reduction in the BMI… |
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| Related Catalog | |
| References |
| Boiling Point | 671.2ºC at 760 mmHg |
|---|---|
| Molecular Formula | C25H27N5O4 |
| Molecular Weight | 461.513 |
| Flash Point | 359.7ºC |
| Exact Mass | 461.206299 |
| PSA | 134.35000 |
| LogP | 2.54458 |
| InChIKey | KEJICOXJTRHYAK-XFULWGLBSA-N |
| SMILES | Cn1c(=O)cc(N2CCCC(N)C2)n(Cc2ccccc2C#N)c1=O.O=C(O)c1ccccc1 |
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Name: Oral bioavailability in monkey
Source: ChEMBL
Target: Macaca mulatta
External Id: CHEMBL1023110
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Name: Bioavailability in monkey at 1.1 mg/kg, iv and 10 mg/kg, po
Source: ChEMBL
Target: Macaca mulatta
External Id: CHEMBL916130
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Name: Enzymatic assay of human HDAC6 with commercial peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808149
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Name: Enzymatic assay of human HDAC6 with custom peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808150
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082
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Name: Half life in monkey at 10 mg/kg, po
Source: ChEMBL
Target: Macaca mulatta
External Id: CHEMBL916126
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Name: Clearance in monkey at 1.1 mg/kg, iv and 10 mg/kg, po
Source: ChEMBL
Target: Macaca mulatta
External Id: CHEMBL916128
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Name: Volume of distribution at steady state in monkey at 1.1 mg/kg, iv and 10 mg/kg, po
Source: ChEMBL
Target: Macaca mulatta
External Id: CHEMBL916129
|
|
Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805
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| Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-, benzoate (1:1) |
| 2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile,benzoic acid |
| SYR 322 |
| Vipidia (TN) |
| Alogliptin (Benzoate) |
| Alogliptin benzoate |
| 2-({6-[(3R)-3-Amino-1-piperidinyl]-3-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl}methyl)benzonitrile benzoate (1:1) |
| 2-({6-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile benzoate (1:1) |
| alogliptin monobenzoate |
| Nesina |
| 2-[6-[3(R)-Aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-ylmethyl]benzonitrile benzoate |