Cinchonine

Modify Date: 2026-07-01 06:03:47

Cinchonine structure	Common Name	Cinchonine
	CAS Number	118-10-5	Molecular Weight	294.39
	Density	1.2±0.1 g/cm3	Boiling Point	464.5±30.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₂₂N₂O	Melting Point	260-263 °C
	MSDS	Chinese USA	Flash Point	234.7±24.6 °C
	Symbol	GHS07	Signal Word	Warning

Use of Cinchonine

Cinchonine is a natural compound present in Cinchona bark. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1].

Name	cinchonine
Synonym	More Synonyms

Description	Cinchonine is a natural compound present in Cinchona bark. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Jin ZL, et al. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15(6):5046-5050.

Density	1.2±0.1 g/cm3
Boiling Point	464.5±30.0 °C at 760 mmHg
Melting Point	260-263 °C
Molecular Formula	C₁₉H₂₂N₂O
Molecular Weight	294.39
Flash Point	234.7±24.6 °C
Exact Mass	294.173218
PSA	36.36000
LogP	3.35
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.652
InChIKey	KMPWYEUPVWOPIM-KAGGUIQQSA-N
SMILES	C=CC1CN2CCC1CC2C(O)c1ccnc2ccccc12
Water Solubility	Insoluble

Cinchonine MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD3500000

CHEMICAL NAME :: Cinchonine

CAS REGISTRY NUMBER :: 118-10-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H22-N2-O

MOLECULAR WEIGHT :: 294.43

WISWESSER LINE NOTATION :: T66 BNJ EYQ- DT66 A B CNTJ A1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 152 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - changes in motor activity (specific assay)

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 4,265,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Cardiac - other changes Lungs, Thorax, or Respiration - respiratory depression Blood - other hemolysis with or without anemia

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 205,129,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Blood - other hemolysis with or without anemia

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 205,129,1948

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H332
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R20/21/22
Safety Phrases	S26-S36-S36/37
RIDADR	1544
WGK Germany	3
RTECS	GD3500000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2933990090

methanesulfonic...

CAS#:560119-43-9

~53%

Cinchonine

CAS#:118-10-5

(1S,2R,3S,5S,6R...

CAS#:560119-45-1

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Literature: Journal of Organic Chemistry, , vol. 69, # 9 p. 2983 - 2991

O-tosylcinchonine

CAS#:189309-24-8

~14%

N/A

CAS#:1393446-38-2

Cinchonine

CAS#:118-10-5

Cinchonine

CAS#:118-10-5

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Literature: Arkivoc, , vol. 2012, # 6 p. 264 - 280

O-tosylcinchonine

CAS#:189309-24-8

~30%

N/A

CAS#:1393446-38-2

Cinchonine

CAS#:118-10-5

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Literature: Arkivoc, , vol. 2012, # 6 p. 264 - 280

O-tosylcinchonine

CAS#:189309-24-8

Cinchonine

CAS#:118-10-5

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Literature: Bulletin des Societes Chimiques Belges, , vol. 106, # 2 p. 77 - 84

Cinchonine

CAS#:118-10-5

Cinchonine

CAS#:118-10-5

Learn More

Literature: Bulletin des Societes Chimiques Belges, , vol. 106, # 2 p. 77 - 84

Cinchonine

CAS#:118-10-5

N/A

CAS#:1393446-38-2

Cinchonine

CAS#:118-10-5

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Literature: Arkivoc, , vol. 2012, # 6 p. 264 - 280

pentanol

CAS#:71-41-0

Cinchonine

CAS#:118-10-5

Cinchonine

CAS#:118-10-5

Cinchonidine

CAS#:485-71-2

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Literature: Justus Liebigs Annalen der Chemie, , vol. 492, p. 242,255

Precursor 4
CAS#:560119-43-9 methanesulfonic... CAS#:189309-24-8 O-tosylcinchonine CAS#:118-10-5 Cinchonine CAS#:71-41-0 pentanol
DownStream 10
CAS#:32644-15-8 (2S)-2-Bromopro... CAS#:10009-70-8 (R)-(+)-2-BROMO... CAS#:536-78-7 3-Ethylpyridine CAS#:1007128-30-4 (1S)-quinolin-4...
CAS#:324757-50-8 R-Clopidogrel C... CAS#:490-11-9 Cinchomeronic acid CAS#:485-65-4 Hydrocinchonine CAS#:95088-20-3 TETRACAINE
CAS#:118-10-5 Cinchonine CAS#:485-71-2 Cinchonidine

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.

Bioorg. Med. Chem. 18 , 2225-31, (2010)

There are many of pathogen parasite species with different susceptibility profile to antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of drugs against only one pa...

Mutation in the Plasmodium falciparum CRT protein determines the stereospecific activity of antimalarial cinchona alkaloids.

Antimicrob. Agents Chemother. 56(10) , 5356-64, (2012)

The Cinchona alkaloids are quinoline aminoalcohols that occur as diastereomer pairs, typified by (-)-quinine and (+)-quinidine. The potency of (+)-isomers is greater than the (-)-isomers in vitro and ...

Thousands of chemical starting points for antimalarial lead identification.

Nature 465 , 305-10, (2010)

Malaria is a devastating infection caused by protozoa of the genus Plasmodium. Drug resistance is widespread, no new chemical class of antimalarials has been introduced into clinical practice since 19...

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN

Name: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Activator_SinglePoint...
Source: Broad Institute
Target: N/A
External Id: 2084-01_Activator_SinglePoint_HTS_Activity

Name: Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc...
Source: The Scripps Research Institute Molecular Screening Center
Target: N/A
External Id: GDH-TPI_INH_ABS_1536_1X%INH CSRUN

Name: Spermicidal activity against human spermatozoa at 10 mg/ml by modified sander-cramer ...
Source: ChEMBL
Target: Spermatozoa
External Id: CHEMBL2072257

Name: Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve...
Source: NCGC
Target: N/A
External Id: OBG420

Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01

Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805

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(1S)-Quinolin-4-yl((2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol

homoquinidine

MFCD00064372

EINECS 204-234-6

cinchonidine

chinchonine

Cinchonine

D-CINCHONINE

Cinchonin

(8α,9S)-Cinchonan-9-ol

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China
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China
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Cinchonine

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