Name | N-Cycloheptyl-2-[(1-methyl-4,5-dihydro-1H-imidazol-2-yl)sulfanyl]-2-phenylacetamide | CAS# | 2559703-06-7 | |
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Price | ¥600.0/100mg ¥1000.0/250mg ¥2000.0/1g | Purity | 98.0% | |
Stocking Period |
1 Day | Stock | 3 | |
Product Webpage: | https://www.dcchemicals.com/product_show-Apostatin-1.html |
Detail
Product Information
Apostatin-1 (Apt-1) is a novel TRADD inhibitor.Apostatin-1 inhibits RIPK1-dependent apoptosis (RDA) with IC50 of 1.28 μM and shows no significant off-target activity on 97 kinases in KINOME scan profiling.Inhibition of TRADD by Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin. Treatment with Apt-1 restored proteostasis and inhibited cell death in a mouse model of proteinopathy induced by mutant tau(P301S). |