N-Cycloheptyl-2-[(1-methyl-4,5-dihydro-1H-imidazol-2-yl)sulfanyl]-2-phenylacetamide
Modify Date: 2024-09-16 21:12:17
![N-Cycloheptyl-2-[(1-methyl-4,5-dihydro-1H-imidazol-2-yl)sulfanyl]-2-phenylacetamide Structure](https://image.chemsrc.com/caspic/482/2559703-06-7.png)
N-Cycloheptyl-2-[(1-methyl-4,5-dihydro-1H-imidazol-2-yl)sulfanyl]-2-phenylacetamide structure
|
Common Name | N-Cycloheptyl-2-[(1-methyl-4,5-dihydro-1H-imidazol-2-yl)sulfanyl]-2-phenylacetamide | ||
|---|---|---|---|---|
| CAS Number | 2559703-06-7 | Molecular Weight | 345.502 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C19H27N3OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of N-Cycloheptyl-2-[(1-methyl-4,5-dihydro-1H-imidazol-2-yl)sulfanyl]-2-phenylacetamideApostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 can bind with TRADD-N (KD=2.17 μM), disrupting its binding to both TRADD-C and TRAF2. Apostatin-1 modulates the ubiquitination of RIPK1 and beclin 1. Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin[1]. |
| Name | N-Cycloheptyl-2-[(1-methyl-4,5-dihydro-1H-imidazol-2-yl)sulfanyl]-2-phenylacetamide |
|---|---|
| Synonym | More Synonyms |
| Description | Apostatin-1 (Apt-1) is a potent TRADD inhibitor. Apostatin-1 can bind with TRADD-N (KD=2.17 μM), disrupting its binding to both TRADD-C and TRAF2. Apostatin-1 modulates the ubiquitination of RIPK1 and beclin 1. Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Apostatin-1 inhibits Velcade (bortezomib)-induced apoptosis and RIPK1-dependent apoptosis (RDA) and necroptosis, with an IC50 of 0.97 μM[1]. Apostatin-1 (10 μM, 6 h) effectively induces autophagy and the degradation of long-lived proteins[1]. Western Blot Analysis[1] Cell Line: SH-SY5Y, HeLa, HT-29, and Jurkat cells Concentration: 10 μM Incubation Time: 6 h Result: Effectively induced autophagy by LC3 II induction and p62 reduction. |
| In Vivo | Apostatin-1 (20 mg/kg, IP, once) inhibits inflammatory responses, and increases survival of systemic inflammation mouse model[1]. Animal Model: Wild-type mice (n = 10, male, 8 weeks of age, systemic inflammation mouse model)[1] Dosage: 20 mg/kg Administration: IP, once Result: Reduced expression of the TNF-induced inflammatory target gene products, NOS and COXII27, and of inflammatory cytokines in cells stimulated with pathogen-associated molecular patterns, including interferon γ (IFNγ), lipopolysaccharide (LPS), Pam3CSK4 (a synthetic bacterial lipopeptide), and muramyl dipeptide (MDP). Showed increased survival following intravenous delivery of TNF, a mouse model of systemic inflammation. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C19H27N3OS |
| Molecular Weight | 345.502 |
| Exact Mass | 345.187469 |
| LogP | 3.63 |
| Index of Refraction | 1.630 |
| Benzeneacetamide, N-cycloheptyl-α-[(4,5-dihydro-1-methyl-1H-imidazol-2-yl)thio]- |
| N-Cycloheptyl-2-[(1-methyl-4,5-dihydro-1H-imidazol-2-yl)sulfanyl]-2-phenylacetamide |