Moracin O
Modify Date: 2025-08-27 16:54:31
Moracin O structure
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Common Name | Moracin O | ||
|---|---|---|---|---|
| CAS Number | 123702-97-6 | Molecular Weight | 326.343 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 557.0±38.0 °C at 760 mmHg | |
| Molecular Formula | C19H18O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 290.6±26.8 °C | |
Use of Moracin OMoracin O is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin O reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin O has neuroprotective and anti-inflammatory effects[1][2][3]. |
| Name | Moracin O |
|---|---|
| Synonym | More Synonyms |
| Description | Moracin O is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin O reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin O has neuroprotective and anti-inflammatory effects[1][2][3]. |
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| Related Catalog | |
| In Vitro | Moracin O enhances cell viability in dose-dependent manner against oxygen-glucose deprivation (OGD)-induced cell death in neuroblastoma SH-SY5Y cells with an EC50 value of 12.6 μM. Moracin O reduces ROS production in OGD-induced cell death (IC50 value of 0.3 μM). Moracin O protects neuronal cell death against the oxidative stress induced by OGD[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 557.0±38.0 °C at 760 mmHg |
| Molecular Formula | C19H18O5 |
| Molecular Weight | 326.343 |
| Flash Point | 290.6±26.8 °C |
| Exact Mass | 326.115417 |
| PSA | 83.06000 |
| LogP | 2.86 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.679 |
| InChIKey | HMTMYIWMPJSCAZ-GOSISDBHSA-N |
| SMILES | CC(C)(O)C1Cc2cc3cc(-c4cc(O)cc(O)c4)oc3cc2O1 |
| Storage condition | 2-8℃ |
| Hazard Codes | Xi |
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Name: Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs ...
Source: ChEMBL
Target: Hypoxia-inducible factor 1-alpha
External Id: CHEMBL1799182
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Name: Inhibition of hypoxia-induced HIF1alpha protein accumulation in nucleus of human Hep3...
Source: ChEMBL
Target: Hypoxia-inducible factor 1-alpha
External Id: CHEMBL1799184
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| 5-[(6R)-6-(2-Hydroxy-2-propanyl)-5,6-dihydrofuro[3,2-f][1]benzofuran-2-yl]-1,3-benzenediol |