Glimepiride-d4-1

Modify Date: 2024-01-20 13:22:26

Glimepiride-d4-1 structure	Common Name	Glimepiride-d4-1
	CAS Number	1131981-29-7	Molecular Weight	494.64
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₃₀D₄N₄O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Glimepiride-d4-1

Glimepiride-d4-1 is deuterium labeled Glimepiride. Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.

Name	Glimepiride-d4
Synonym	More Synonyms

Description	Glimepiride-d4-1 is deuterium labeled Glimepiride. Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Geisen, K., Special pharmacology of the new sulfonylurea glimepiride. Arzneimittelforschung, 1988. 38(8): p. 1120-30. [3]. Liu, F., et al., Glimepiride attenuates Abeta production via suppressing BACE1 activity in cortical neurons. Neurosci Lett, 2013. 557 Pt B: p. 90-4. [4]. Basit, A., M. Riaz, and A. Fawwad, Glimepiride: evidence-based facts, trends, and observations (GIFTS). [corrected]. Vasc Health Risk Manag, 2012. 8: p. 463-72.

Molecular Formula	C₂₄H₃₀D₄N₄O₅S
Molecular Weight	494.64
Exact Mass	494.25000
PSA	133.06000
LogP	5.26540

Glimepiride D4