Zileuton-d4

Modify Date: 2024-09-05 18:41:10

Zileuton-d4 Structure
Zileuton-d4 structure
Common Name Zileuton-d4
CAS Number 1189878-76-9 Molecular Weight 240.31500
Density N/A Boiling Point N/A
Molecular Formula C11H8D4N2O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Zileuton-d4


Zileuton-d4 (A 64077-d4) is the deuterium labeled Zileuton. Zileuton (A 64077) is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties[1][2].

 Names

Name 1-[1-(1-benzothiophen-2-yl)-1,2,2,2-tetradeuterioethyl]-1-hydroxyurea
Synonym More Synonyms

 Zileuton-d4 Biological Activity

Description Zileuton-d4 (A 64077-d4) is the deuterium labeled Zileuton. Zileuton (A 64077) is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Abueid L, et al. Inhibition of 5-lipoxygenase by zileuton in a rat model of myocardial infarction. Anatol J Cardiol. 2016 Nov 10

[3]. Kuvibidila S, et al. Hydroxyurea and Zileuton Differentially Modulate Cell Proliferation and Interleukin-2 Secretion by Murine Spleen Cells: Possible Implication on the Immune Function and Risk of Pain Crisis in Patients with Sickle Cell Disease. Ochsner

[4]. Gounaris E, et al. Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation. PLoS One. 2015 Mar 6;10(3):e0121402

 Chemical & Physical Properties

Molecular Formula C11H8D4N2O2S
Molecular Weight 240.31500
Exact Mass 240.08700
PSA 95.79000
LogP 3.24600

 Synonyms

Leutrol-d4
Zyflo-d4
Zileuton-d4