JAK3/BTK-IN-6
Modify Date: 2024-04-06 16:11:43
JAK3/BTK-IN-6 structure
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Common Name | JAK3/BTK-IN-6 | ||
|---|---|---|---|---|
| CAS Number | 2243136-03-8 | Molecular Weight | 455.20 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H17BF3N5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JAK3/BTK-IN-6JAK3/BTK-IN-6 (compound 14h) is a potent BTK and JAK3 dual inhibitor, with IC50 values of 0.6 and 0.4 nM, respectively. JAK3/BTK-IN-6 shows good metabolic stability in human liver microsome. JAK3/BTK-IN-6 can be used for hematological and immune diseases research[1]. |
| Name | JAK3/BTK-IN-6 |
|---|
| Description | JAK3/BTK-IN-6 (compound 14h) is a potent BTK and JAK3 dual inhibitor, with IC50 values of 0.6 and 0.4 nM, respectively. JAK3/BTK-IN-6 shows good metabolic stability in human liver microsome. JAK3/BTK-IN-6 can be used for hematological and immune diseases research[1]. |
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| Related Catalog | |
| Target |
JAK3:0.4 nM (IC50) JAK2:657.9 nM (IC50) JAK1:>1000 nM (IC50) Tyk2:>1000 nM (IC50) |
| In Vitro | JAK3/BTK-IN-6 (compound 14h) shows antiproliferative activities against hematopoietic cells (Raji, Romas, HEL, Jeko-1, and OCI-LY10), with IC50 values of 1.7, 0.5, 1.1, 0.5, and 1-10, respectively[1]. |
| References |
| Molecular Formula | C21H17BF3N5O3 |
|---|---|
| Molecular Weight | 455.20 |