PD 90780

Modify Date: 2024-01-09 09:43:31

PD 90780 structure	Common Name	PD 90780
	CAS Number	77422-99-2	Molecular Weight	362.34
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₄N₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PD 90780

PD 90780 is a non peptide antagonist of nerve growth factor (NGF) binding to the P75 NGF receptor, inhibits NGF-p75 NTR interaction with IC50s values of 23.1 µM and 1.8 µM in PC12 cells and PC12 nnr5 cells, respectively [1] .

Name	pd 90780
Synonym	More Synonyms

Description	PD 90780 is a non peptide antagonist of nerve growth factor (NGF) binding to the P75 NGF receptor, inhibits NGF-p75 NTR interaction with IC50s values of 23.1 µM and 1.8 µM in PC12 cells and PC12 nnr5 cells, respectively [1] .
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	IC50: 23.1 µM (NGF, PC12 cells), 1.8 µM (NGF, PC12 nnr5 cells)
References	[1]. Colquhoun A , et al. Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J Pharmacol Exp Ther. 2004 Aug;310(2):505-11.

Molecular Formula	C₁₉H₁₄N₄O₄
Molecular Weight	362.34
Exact Mass	362.10200
PSA	105.70000
LogP	2.20970

7-(benzoylamino)-4,9-dihydro-4-methyl-9-oxopyrazolo[5,1-b]quinazoline-2-carboxylic acid

7-Benzoylamino-4-methyl-9-oxo-4,9-dihydro-pyrazolo[5,1-b]quinazoline-2-carboxylic acid

7-(Benzoylamino)-4,9-dihydro-4-methyl-9-oxopyrazolo-[5,1-b]quinazoline-2-carboxylic acid

PD 90780

Use of PD 90780

Names

PD 90780 Biological Activity

Chemical & Physical Properties

Synonyms