831217-43-7

831217-43-7 structure

Name: 116-9e
Chemical Name: 6-[4-methyl-2-oxo-5-phenylmethoxycarbonyl-6-(4-phenylphenyl)-1,6-dihydropyrimidin-3-yl]hexanoic acid
CAS Number: 831217-43-7
Molecular Formula: C₃₁H₃₂N₂O₅
Molecular Weight: 512.60
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2017-04-06 15:03:28
Modify Date: 2024-01-07 20:05:50
116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg)’s endogenous ATPase activity and the TAg-mediated activation of Hsp70[1][2].

Name	6-[4-methyl-2-oxo-5-phenylmethoxycarbonyl-6-(4-phenylphenyl)-1,6-dihydropyrimidin-3-yl]hexanoic acid
Synonyms	upcmld00wmal2-11b hms2227g12 upcmld00wmal2-11b:004 upcmld00wmal2-11b:002 upcmld00wmal2-11b:003

Description	116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg)’s endogenous ATPase activity and the TAg-mediated activation of Hsp70[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Target	Simian Virus 40 (SV40) [1] Hsp70 co-chaperone DNAJA1[2]
In Vitro	116-9e (MAL2-11B) inhibits TAg stimulation of Hsp70 with greater efficacy than MAL3-101, significantly reduces viral replication and DNA synthesis. MAL2-11B also inhibits the activity of the TAg ATPase domain[1]. 116-9e (MAL2-11B; 15 µM; 5 days) significantly reduces the growth of BK virus in a human kidney cell line[1].
References	[1]. Christine M Wright, et al. Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Res. 2009 Apr;141(1):71-80. [2]. Nitika, et al. Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance. Sci Rep. 2020 Aug 14;10(1):13831.

1468-42-4

5396-89-4

3218-36-8

~76%

831217-43-7

Literature: Werner, Stefan; Turner, David M.; Lyon, Michael A.; Huryn, Donna M.; Wipf, Peter Synlett, 2006 , # 14 p. 2334 - 2338

Precursor 3
1468-42-4 5396-89-4 3218-36-8
DownStream 0