116-9e

Modify Date: 2024-01-07 20:05:50

116-9e structure	Common Name	116-9e
	CAS Number	831217-43-7	Molecular Weight	512.60
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₁H₃₂N₂O₅	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS06, GHS09	Signal Word	Danger

Use of 116-9e

116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg)’s endogenous ATPase activity and the TAg-mediated activation of Hsp70[1][2].

Name	6-[4-methyl-2-oxo-5-phenylmethoxycarbonyl-6-(4-phenylphenyl)-1,6-dihydropyrimidin-3-yl]hexanoic acid
Synonym	More Synonyms

Description	116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg)’s endogenous ATPase activity and the TAg-mediated activation of Hsp70[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Target	Simian Virus 40 (SV40) [1] Hsp70 co-chaperone DNAJA1[2]
In Vitro	116-9e (MAL2-11B) inhibits TAg stimulation of Hsp70 with greater efficacy than MAL3-101, significantly reduces viral replication and DNA synthesis. MAL2-11B also inhibits the activity of the TAg ATPase domain[1]. 116-9e (MAL2-11B; 15 µM; 5 days) significantly reduces the growth of BK virus in a human kidney cell line[1].
References	[1]. Christine M Wright, et al. Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Res. 2009 Apr;141(1):71-80. [2]. Nitika, et al. Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance. Sci Rep. 2020 Aug 14;10(1):13831.

Molecular Formula	C₃₁H₃₂N₂O₅
Molecular Weight	512.60
Exact Mass	512.23100
PSA	99.43000
LogP	5.66020
Storage condition	2-8°C

116-9e MSDS(Chinese)

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301-H410
Precautionary Statements	P273-P301 + P310-P501
Hazard Codes	T
Risk Phrases	25-50/53
Safety Phrases	45-60-61
RIDADR	UN 2811 6.1 / PGIII

6-(Carbamoylami...

CAS#:1468-42-4

Benzyl acetylacetate

CAS#:5396-89-4

4-Biphenylcarba...

CAS#:3218-36-8

~76%

116-9e

CAS#:831217-43-7

Literature: Werner, Stefan; Turner, David M.; Lyon, Michael A.; Huryn, Donna M.; Wipf, Peter Synlett, 2006 , # 14 p. 2334 - 2338

Precursor 3
CAS#:1468-42-4 6-(Carbamoylami... CAS#:5396-89-4 Benzyl acetylacetate CAS#:3218-36-8 4-Biphenylcarba...
DownStream 0

upcmld00wmal2-11b

hms2227g12

upcmld00wmal2-11b:004

upcmld00wmal2-11b:002

upcmld00wmal2-11b:003

116-9e

Use of 116-9e

Names

116-9e Biological Activity

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MSDS

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Precursor & DownStream

Synonyms