39026-92-1

39026-92-1 structure

Name: 9-Methoxycamptothecine
Chemical Name: 9-Methoxycamptothecin
CAS Number: 39026-92-1
Molecular Formula: C₂₁H₁₈N₂O₅
Molecular Weight: 378.378
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-11-21 19:42:14
Modify Date: 2024-01-02 15:52:12
9-Methoxycamptothecin (MCPT), isolated from Nothapodytes foetida, has antitumor activities through topoisomerase inhibition. 9-Methoxycamptothecin (MCPT) induces strong G2/M arrest and apoptosis in cancer[1][2].

Name	9-Methoxycamptothecin
Synonyms	1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-methoxy-, (4S)- 10-methoxycamptothecin 9-methoxycamtothecin (4S)-4-Ethyl-4-hydroxy-10-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Camptothecin,9-methoxy

Description	9-Methoxycamptothecin (MCPT), isolated from Nothapodytes foetida, has antitumor activities through topoisomerase inhibition. 9-Methoxycamptothecin (MCPT) induces strong G2/M arrest and apoptosis in cancer[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase[1]. Apoptosis[2].
References	[1]. Liao N, et al. 9-methoxycamptothecin from Nothapodytes foetida induces apoptosis in murine sarcoma S180 cells. Z Naturforsch C. 2011 Sep-Oct;66(9-10):471-6. [2]. Wang H, et al. TNFα and Fas/FasL pathways are involved in 9-Methoxycamptothecin-induced apoptosis in cancer cells with oxidative stress and G2/M cell cycle arrest. Food Chem Toxicol. 2013 May;55:396-410.

91421-42-0

39026-92-1

186581-53-3

67656-30-8

~94%

39026-92-1

Literature: Sawada; Matsuoka; Nokata; Nagata; Furuta; Yokokura; Miyasaka Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 12 p. 3183 - 3188

91421-43-1

39026-92-1

7689-03-4

39026-92-1