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80214-83-1

80214-83-1 structure
80214-83-1 structure
  • Name: Roxithromycin
  • Chemical Name: (E)-roxithromycin
  • CAS Number: 80214-83-1
  • Molecular Formula: C41H76N2O15
  • Molecular Weight: 837.047
  • Catalog: API Antibiotics Macrolide drug
  • Create Date: 2018-02-06 08:00:00
  • Modify Date: 2024-01-02 18:00:29
  • Roxithromycin is a semi-synthetic macrolide antibiotic.Target: AntibacterialRoxithromycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin is derived from erythromycin, containing the same 14-membered lactone ring. Roxithromycin prevents bacteria from growing, by interfering with their protein synthesis. Roxithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides. Roxithromycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila. From Wikipedia.

Name (E)-roxithromycin
Synonyms Roxid
Overal
Forilin
MFCD00214389
Roxithromycin
Claramid
biaxsig
RU 965
Assoral
roxyithromycin
Brilid
(3R,4S,5S,6R,7R,9R,10E,11S,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-10-{[(2-methoxyethoxy)methoxy]imino}-3,5,7,9,11,13-hexamethyloxacyclotetradecan-2-one
Rulid
Surlid
Description Roxithromycin is a semi-synthetic macrolide antibiotic.Target: AntibacterialRoxithromycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin is derived from erythromycin, containing the same 14-membered lactone ring. Roxithromycin prevents bacteria from growing, by interfering with their protein synthesis. Roxithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides. Roxithromycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila. From Wikipedia.
Related Catalog
References

[1]. http://en.wikipedia.org/wiki/Roxithromycin

Density 1.3±0.1 g/cm3
Boiling Point 864.7±75.0 °C at 760 mmHg
Melting Point 115- 120ºC
Molecular Formula C41H76N2O15
Molecular Weight 837.047
Flash Point 476.7±37.1 °C
Exact Mass 836.524597
PSA 216.89000
LogP 3.73
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.535
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KF4990000
CHEMICAL NAME :
Erythromycin, 9-O-((2-methoxyethoxy)methyl)oxime
CAS REGISTRY NUMBER :
80214-83-1
LAST UPDATED :
199806
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C41-H76-N2-O15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
830 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 36(Suppl 4),94,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
665 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1471,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
.2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,1471,1995
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R22
Safety Phrases 26
RIDADR NONH for all modes of transport
RTECS KF4990000
HS Code 2941500000

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80214-83-1 structure

80214-83-1

Literature: EP1435359 A1, ; Page 5 ;
Precursor  2

DownStream  0

HS Code 2941500000