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85079-48-7

85079-48-7 structure
85079-48-7 structure
  • Name: Brevetoxin-3
  • Chemical Name: Brevetoxin 3
  • CAS Number: 85079-48-7
  • Molecular Formula: C50H72O14
  • Molecular Weight: 897.09800
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
  • Create Date: 2016-04-02 08:30:07
  • Modify Date: 2024-01-13 16:10:06
  • Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain)[1]. Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation[2].

Name Brevetoxin 3
Synonyms GB 3 toxin
T-17 toxin
Brevetoxin PbTx 3
PbTx 3
GB 3
[3H]-PbTx 3
Brevetoxin T17
brevetoxin-3
Toxin T-17
Ptychodiscus brevis toxin 3
Description Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain)[1]. Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation[2].
Related Catalog
Target

IC50: voltage-gated Na+ channel[1]

In Vitro Brevetoxin-3 (PbTx-3)(30-500 nM) produces a shift in activation to more negative membrane potentials whereby single-channel activity is observed under steady-state conditions (maintained depolarization at -50 mV)[1].
In Vivo Brevetoxin-3 (PbTx-3)(intratracheal instillation; 2.8 μg/kg; gestational days 15-18) radioactivity is detected in placentas and fetuses within 0.5 hours. Concentrations of brevetoxin equivalents in fetuses are approximately 0.3 ng/g throughout the 48-h post-dosing, resulting in a calculated dose to fetuses of 19 ng/gh. Following brevetoxin infusion, concentration of brevetoxin equivalents in fetuses is 0.1 ng/g, lower than that present in most maternal tissues[3]. . Animal Model: Pregnant CD-1 mice[3] Dosage: 2.8 μg/kg Administration: Intratracheal instillation; 2.8 μg/kg; gestational days 15–18 Result: Demonstrated placental transport of brevetoxin or its metabolites following maternal acute exposure. 
References

[1]. Jeglitsch G,et al. Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons.J Pharmacol Exp Ther. 1998 Feb;284(2):516-25.

[2]. Zaias J,et al. Repeated exposure to aerosolized brevetoxin-3 induces prolonged airway hyperresponsiveness and lung inflammation in sheep.Inhal Toxicol. 2011 Mar;23(4):205-11.

[3]. Benson JM, et al. Placental transport of brevetoxin-3 in CD-1 mice.Toxicon. 2006 Dec 15;48(8):1018-26. Epub 2006 Aug 18.

Density 1.187g/cm3
Molecular Formula C50H72O14
Molecular Weight 897.09800
Exact Mass 896.49200
PSA 159.06000
LogP 5.26550
Index of Refraction 1.52

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XW5885000
CHEMICAL NAME :
Toxin T-17
CAS REGISTRY NUMBER :
85079-48-7
LAST UPDATED :
198509

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
520 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
170 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
94 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982
RIDADR UN 3172
Hazard Class 6.1(a)
Precursor  0

DownStream  1