7279-75-6

7279-75-6 structure

Name: 4-[1-HYDROXY-2-([1-METHYLETHYL]AMINO)BUTYL]-1,2-BENZENEDIOL METHANESULFONATE
Chemical Name: 4-[1-hydroxy-2-(propan-2-ylamino)butyl]benzene-1,2-diol,methanesulfonic acid
CAS Number: 7279-75-6
Molecular Formula: C₁₄H₂₅NO₆S
Molecular Weight: 335.41600
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-07-12 22:12:54
Modify Date: 2024-01-05 19:30:50
Isoetharine (Isoetarine) mesylate is an orally active selective agonist of β-adrenergic receptors. Isoetharine mesylate is a catechol-like drug and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine mesylate can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator[1][2].

Name	4-[1-hydroxy-2-(propan-2-ylamino)butyl]benzene-1,2-diol,methanesulfonic acid
Synonyms	Isoetharine mesylate salt 4-[1-Hydroxy-2-[(1-methylethyl)amino]butyl]-1,2-benzenediol mesylate salt EINECS 230-695-8 1,2-Benzenediol,4-(1-hydroxy-2-((1-methylethyl)amino)-butyl)-,methanesulfonate (salt) Isotharine mesylate ISOETHARINE MESYLATE Isoetharine mesylate (USP) Isoetarine mesilate

Description	Isoetharine (Isoetarine) mesylate is an orally active selective agonist of β-adrenergic receptors. Isoetharine mesylate is a catechol-like drug and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine mesylate can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology
In Vitro	Isoetharine mesylate (50 μM, 18 hours) can induce the production and release of [35S]sulfated metabolites of catecholic drugs in HepG2 human hepatoma cells[1].
In Vivo	Isoetharine mesylate inhibits melanin deposition with the AC50 value of 5.10 mM and complete inhibition of pigment production at 7.50 mM in the zebrafish larvae model[2].
References	[1]. Katsuhisa Kurogi，et al. Concerted actions of the catechol O-methyltransferase and the cytosolic sulfotransferase SULT1A3 in the metabolism of catecholic drugs. Biochem Pharmacol. 2012 Nov 1;84(9):1186-95. [2]. Monika Maciag，et al. Evaluation of β-adrenergic ligands for development of pharmacological heart failure and transparency models in zebrafish. Toxicol Appl Pharmacol. 2022 Jan 1;434:115812.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H332
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	20/21/22
Safety Phrases	36
RIDADR	NONH for all modes of transport