3482-37-9

• 常用中文名：三甲基秋水仙酸
• 常用英文名：Trimethylcolchicinic acid
• CAS号：3482-37-9
• 分子式：C₁₉H₂₁NO₅
• 分子量：343.37400
• 相关类别： 分析化学 标准品 法医和兽医标准品
• 发布时间：2018-05-15 08:00:00
• 更新时间：2026-07-16 09:46:30
• Trimethylcolchicinic acid is an antimitotic agent disrupting microtubule action through the binding of tubulin and preventing polymerization. Has been shown to stimulate the intrinsic GTPase activity of tubulin. Induces apoptosis and activates the JNK/SAPK signals.

名称

• 中文名: 三甲基秋水仙素酸
• 英文名: N-Deacetyl Colchiceine
• 中文别名: 三甲基秋水仙素酸(秋水仙碱杂质33); N-脱乙酰基10-脱甲基秋水仙碱
• 英文别名: Trimethyl Colchicine Acid; trimethylcolchicinic acid; N-Deacetyl 10-Demethyl Colchicine; trimethyl-colchicinicaci; Aids-002892; (S)-7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxybenzo[a]htalen-9(5H)-one; (7S)-7-Amino-6,7-dihydro-10-hydroxy-1,2,3-triMethoxy-benzo[a]htalen-9(5H)-one; Aids002892; Desacetylcolchiceine; TRIMETHYLCOLCHICINIC ACID; 7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-benzo(a)htalen-9(5h)-on; n-deacetyl-colchicein; Deacetylcolchiceine; deacetylcholchiceine; Benzo[a]htalen-9(5H)-one, 7-amino-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-, (7S); N-DEACETYLCOLCHICEINE; desacetylcholchiceine

物化性质

• 密度: 1.32g/cm3
• 沸点: 629ºC at 760mmHg
• 熔点: >230ºC (dec.)
• 分子式: C₁₉H₂₁NO₅
• 分子量: 343.37400
• 闪点: 334.2ºC
• 精确质量: 343.14200
• PSA: 91.01000
• LogP: 3.09150
• 折射率: 1.628
• 储存条件: −20°C

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GH0960000 CHEMICAL NAME : Colchicinic acid, trimethyl- CAS REGISTRY NUMBER : 3482-37-9 BEILSTEIN REFERENCE NO. : 3008992 LAST UPDATED : 199612 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C19-H21-N-O5 MOLECULAR WEIGHT : 343.41 WISWESSER LINE NOTATION : L B677 MV&T&J CO1 DO1 EO1 JZ NQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 23 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Blood - hemorrhage TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 130 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Amphibian - frog DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : Mutation test systems - not otherwise specified MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : 200 mg/kg REFERENCE : CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 3,134,1950

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H312-H332
• 警示性声明: P280
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): 20/21/22
• 安全声明 (欧洲): 36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: GH0960000

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