68181-17-9

68181-17-9 structure

Name: SPDP
Chemical Name: N-Succinimidyl 3-(2-Pyridyldithio)propionate
CAS Number: 68181-17-9
Molecular Formula: C₁₂H₁₂N₂O₄S₂
Molecular Weight: 312.365
Catalog: Research Areas Others
Create Date: 2018-12-23 18:14:41
Modify Date: 2025-08-20 20:42:52
SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP .

Name	N-Succinimidyl 3-(2-Pyridyldithio)propionate
Synonyms	MFCD00009636 1-{[3-(2-Pyridinyldisulfanyl)propanoyl]oxy}-2,5-pyrrolidinedione EINECS 269-034-3 N-succinimidyl 3-(2-pyridyldithio)-propionate (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate 1-{[3-(Pyridin-2-yldisulfanyl)propanoyl]oxy}pyrrolidine-2,5-dione 2,5-Pyrrolidinedione, 1-[1-oxo-3-(2-pyridinyldithio)propoxy]- 1-(1-Oxo-3-(2-pyridyldithio)propoxy)pyrrolidine-2,5-dione 2,5-Pyrrolidinedione, 1-(1-oxo-3-(2-pyridinyldithio)propoxy)- SPDP

Description	SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. equal amounts of anti-CD11c and anti-CTLA-4 Abs (in borate buffered saline; pH 8.5) were activated using SPDP .
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7. [2]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3

6066-82-6

68617-64-1

~79%

68181-17-9

Literature: Shval'e, A. F.; Ofitserov, V. I.; Samukov, V. V. J. Gen. Chem. USSR (Engl. Transl.), 1985 , vol. 55, # 9 p. 2152,1909 - 1910

6066-82-6

119023-08-4

~74%

68181-17-9

Literature: Loccufier, J.; Schacht, E. Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 7 p. 535 - 540

2127-03-9

68181-17-9

Literature: Journal of the American Chemical Society, , vol. 129, # 31 p. 9640 - 9649

2637-34-5

2127-03-9

107-96-0

221180-71-8

Detail

Literature: US4149003 A1, ;

59089-57-5

68181-17-9

Literature: J. Gen. Chem. USSR (Engl. Transl.), , vol. 55, # 9 p. 2152,1909 - 1910

119023-07-3

68181-17-9

Literature: Bulletin des Societes Chimiques Belges, , vol. 97, # 7 p. 535 - 540