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154-87-0

154-87-0 structure
154-87-0 structure
  • Name: Cocarboxylase
  • Chemical Name: thiamine(1+) diphosphate
  • CAS Number: 154-87-0
  • Molecular Formula: C12H19ClN4O7P2S
  • Molecular Weight: 460.767
  • Catalog: API Vitamins and minerals Vitamin B drugs
  • Create Date: 2018-04-26 08:00:00
  • Modify Date: 2026-07-02 14:30:05
  • Thiamine pyrophosphate is the coenzyme form of Vitamin B1 and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.
Name thiamine(1+) diphosphate
Synonyms Vitamin B1 Pyrophosphoric Acid Ester Chloride
thiaminpyrophosphate
pyruvodehydrase
COCBOXYLASE CHLORIDE
thiamine,trihydrogenpyrophosphate(ester)
Thiaminyrophosphatehydrochloride
metabolase
ThiazoliuM,3-[(4-amino-2-Methyl-5-pyriMidinyl)Methyl]-4-Methyl-5-(4,6,6-trihydroxy-4,6-dioxido-3,5-dioxa-4,6-diphosphahex-1-yl)-,chloride (1:1)
Vitamin B1 Pyrophosphate Chloride
Thiamine pyrophosphate
3-((4-Amino-2-methylpyrimidin-5-yl)
thiaminyrophosphoricester
bioxylasi
berolase
[2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-1-thia-3-azoniacyclopenta-2,4-dien-5-yl]ethoxy-hydroxy-phosphoryl]oxyphosphonic acid
thiamine(1+) diphosphate chloride
THIAMINE PYROPHOSPHORIC ACID ESTER CHLORIDE
Thiamine Diphosphate Ester Chloride
pyrolase
THIAMINE PYROPHOSPHATE CHLORIDE
cocbina
3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-[2-[[hydroxy(phosphonooxy)phosphinyl]oxy]ethyl]-4-methylthiazolium Chloride
THIAMINE PYROPHOSPHATE
Thiamine pyrophosphate,Aneurinyrophosphoric acid, Cocboxylase, Thiamine pyrophosphate chloride
fmaneurina
THIAMINIUM PYROPHOSPHORIC ACID ESTER CHLORIDE
THIAMINYROPHOSPHORIC ACID
5-(2-((hydroxy(phosphonooxy)
Vitamin B1 pyrophosphate chloride
Thiamine Pyrophosphoric Acid Ester Chloride
[2-[3-[(4-Amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-5-yl]ethoxy-hydroxy-phosphoryl]oxyphosphonic acid chloride
thiamine diphosphate
diphosphothiamin
Vitamin B1
Cocboxylase Vitamin B1 Pyrophosphoric Acid Ester Chloride
roxy-3,5-dioxa-4,6-diphosphahex-1-yl)-,chloride,p,p’-dioxide
biosyth
bivitasi
Thiazolium, 3-(4-amino-2-methyl-5-pyrimidinyl)methyl-4-methyl-5-(4,6,6-trihydroxy-4,6-dioxido-3,5-dioxa-4,6-diphosphahex-1-yl)-, chloride
VITAMIN B1 PYROPHOSPHORIC ACID ESTER CHLORIDE
thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihyd
3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihydroxy-3,5-dioxa-4,6-diphosphahex-1-yl)thiazolium Chloride P,P'-Dioxide
cocarboxylasum [INN_la]
Aneurinepyrophosphoric acid Cocarboxylase Thiamine pyrophosphate chloride
COCBOXYLASE
TPP (VAN)
Thiamine diphosphate chloride
Thiamine Impurity 30（Thiamine Pyrophosphate）
THIAMINIUM DIPHOSPHORIC ACID ESTER CHLORIDE
tdp(thiaminester)
3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium chloride
TDP
nutrase
phosphoryl)
4-methylthiazol-3-ium chloride
thiamin diphosphate
thiamine-pp
cocboxil
THIAMINIUM PYROPHOSPHATE CHLORIDE
3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium chloride
Aneurinyrophosphoric acid, Cocboxylase, Thiamine pyrophosphate chloride
MFCD00038740
Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihydroxy-3,5-dioxa-4,6-diphosphahex-1-yl)-,chloride,P,P’-dioxide
b-neurox
co-bi
diphosphothiamine
coenbione
3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihydroxy-4,6-dioxido-3,5-dioxa-4,6-diphosphahex-1-yl)thiazolium Chloride
Co-B1
tpp
EINECS 205-230-7
Bioxilasi
thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-[2-[[hydroxy(phosphonooxy)phosphinyl]oxy]ethyl]-4-methyl-, chloride (1:1)
ANEURINYROPHOSPHORIC ACID
tpp(coenzyme)
3-((4-Amino-2-methylpyrimidin-5-yl)methyl)-5-(2-((hydroxy(phosphonooxy)phosphoryl)oxy)ethyl)-4-methylthiazol-3-ium chloride
Thiamine, pyrophosphoric acid ester
coxylase
Thiamine Pyrophosphate Chloride
Thiamin diphosphate chloride
Description Thiamine pyrophosphate is the coenzyme form of Vitamin B1 and is a required intermediate in the pyruvate dehydrogenase complex and the ketoglutarate dehydrogenase complex.
Related Catalog
Target

Human Endogenous Metabolite

Molecular Formula C12H19ClN4O7P2S
Molecular Weight 460.767
Exact Mass 460.013824
PSA 216.83000
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XI7552000
CHEMICAL NAME :
Thiamine, trihydrogen pyrophosphate (ester)
CAS REGISTRY NUMBER :
154-87-0
LAST UPDATED :
199806
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C12-H19-N4-O7-P2-S.Cl
MOLECULAR WEIGHT :
460.80
WISWESSER LINE NOTATION :
T6N CNJ B1 DZ E1- AT5K CSJ D2OPQO&OPQQO E1 &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,471,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
465 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,471,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,1025,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,471,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
360 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,471,1995
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,1025,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3828 No. of Facilities: 172 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 850 (estimated) No. of Female Employees: 766 (estimated)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Risk Phrases R22
Safety Phrases S22-S24/25
RIDADR 1759
WGK Germany 3
RTECS XI7552000
Packaging Group III
Hazard Class 8
50851-39-3 structure

50851-39-3

67-03-8 structure

67-03-8

~%

154-87-0 structure

154-87-0

10023-48-0 structure

10023-48-0

Literature: Justus Liebigs Annalen der Chemie, , vol. 618, p. 210,215, 219 Yakugaku Zasshi, , vol. 76, p. 1314,1317 Chem.Abstr., , p. 3607 Helvetica Chimica Acta, , vol. 32, p. 1478,1483 Journal of Vitaminology, , vol. 5, p. 44,49
4066-53-9 structure

4066-53-9

~%

154-87-0 structure

154-87-0

Literature: Chemische Berichte, , vol. 95, p. 767 - 772
2606-90-8 structure

2606-90-8

2908-71-6 structure

2908-71-6

~%

154-87-0 structure

154-87-0

Literature: Chemische Berichte, , vol. 95, p. 767 - 772
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