Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: α-Carotene
Price: ￥4998.0/1mg
Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Alpha Carotene
Price: ￥Inquiry/1kg
Purity: 99.5%
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Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: β-carotene
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
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Contact: Anson

7488-99-5

7488-99-5 structure

7488-99-5 structure

Name: α-Carotene
Chemical Name: (6'R)-β,ε-carotene
CAS Number: 7488-99-5
Molecular Formula: C₄₀H₅₆
Molecular Weight: 536.873
Catalog: Food additive Nutrition supplements Vitamins
Create Date: 2018-08-07 17:28:09
Modify Date: 2024-01-02 18:15:11
α-Carotene, a precursor of vitamin A, is used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs. α-Carotene is isolated from yellow-orange and dark-green vegetables[1][2].

Name	(6'R)-β,ε-carotene
Synonyms	1,3,3-Triméthyl-2-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tétraméthyl-18-(2,6,6-triméthyl-2-cyclohexén-1-yl)-1,3,5,7,9,11,13,15,17-octadécanonaèn-1-yl]cyclohexène CISALPHA-CAROTENE Carotene 1,3,3-Trimethyl-2-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyl-18-(2,6,6-trimethyl-2-cyclohexen-1-yl)-1,3,5,7,9,11,13,15,17-octadecanonaen-1-yl]cyclohexen Renieratene (6'R)-beta,epsilon-carotene Isorenieratene A-CAROTENE MFCD00136012 CAROTENE,A α-Carotene 1,3,3-Trimethyl-2-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyl-18-(2,6,6-trimethyl-2-cyclohexen-1-yl)-1,3,5,7,9,11,13,15,17-octadecanonaen-1-yl]cyclohexene all-trans-α-carotene β,β-Carotene, 4,5-didehydro-5,6-dihydro- 4,5-Didehydro-5,6-dihydro-β,β-carotene (+)-α-Carotene

Description	α-Carotene, a precursor of vitamin A, is used as an anti-metastatic agent or as an adjuvant for anti-cancer drugs. α-Carotene is isolated from yellow-orange and dark-green vegetables[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	α-Carotene (0.5-2.5 μM; 24 hours) significantly increases protein expression of TIMP-1 and TIMP-2 in a concentration-dependent manner in LLC cells. AC (0.5-2.5 μM) significantly increases PAI-1 protein expression. α-Carotene (2.5 μM) also significantly inhibits integrin β1-mediated phosphorylation of focal adhesion kinase (FAK) which then decreased the phosphorylation of MAPK family[2]. α-Carotene (0.5, 1, 2.5 μM; 48 hours) significantly and concentration-dependently inhibits invasion of LLC during 48 h of incubation[2]. α-Carotene (0.5, 1, 2.5 μM; 24 hours) significantly decreases activities of MMP-9, -2 and uPA in concentration-dependent manner in LLC cells[2]. α-Carotene (2, 5, 10 μM; 7 days) inhibits the proliferation of the human neuroblastoma cell line GOTO in a dose- and time-dependent manner. α-Carotene (5 μM; 48 hours) halts the cell cycle at the G0/G1 phase concomitantly with a reduction in the mRNA expression of the protooncogene N-Myc[3]. Western Blot Analysis[2] Cell Line: Lewis lung carcinoma (LLC) cells Concentration: 0.5, 1, 2.5 μM Incubation Time: 24 hours Result: Significantly increased protein expression of TIMP-1 and TIMP-2 in a concentration-dependent manner in LLC cells.
In Vivo	α-Carotene (5 mg/kg; oral; twice a week; for additional 3 weeks) alone significantly decreases lung metastasis without affecting primary tumor growth[2]. Animal Model: C57BL/6 male mice (4 weeks old; 20-25 g) with LLC cells[2] Dosage: 5 mg/kg Administration: Oral; twice a week; for additional 3 weeks Result: Significantly decreased lung metastasis.
References	[1]. Bushway, R.J., et al. Determination of α- and β-carotene in fruit and vegetables by high performance liquid chromatography. Can. Inst. Food Sci. Technol. J. 15(3), 165-169 (1982). [2]. Liu YZ, et al. Alpha-carotene inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lungmetastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice. J Nutr Biochem. 2015 Jun;26(6):607-15. [3]. Murakoshi M, et al. Inhibitory effects of alpha-carotene on proliferation of the human neuroblastoma cell line GOTO. J Natl Cancer Inst. 1989 Nov 1;81(21):1649-52.

Density	0.9±0.1 g/cm3
Boiling Point	644.9±35.0 °C at 760 mmHg
Melting Point	185ºC
Molecular Formula	C₄₀H₅₆
Molecular Weight	536.873
Flash Point	341.2±20.8 °C
Exact Mass	536.438232
LogP	15.45
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.563
Storage condition	-20°C

Hazard Codes	Xn
Risk Phrases	40
Safety Phrases	S36/37
RIDADR	UN 1593 6.1/PG 3
Packaging Group	II; III
Hazard Class	4.1

6060-33-9 structure

6060-33-9

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7488-99-5 structure

7488-99-5

Literature: Phytochemistry (Elsevier), , vol. 6, p. 1119 - 1126

15678-54-3 structure

15678-54-3

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7488-99-5 structure

7488-99-5

Literature: Phytochemistry (Elsevier), , vol. 6, p. 1119 - 1126

125069-77-4 structure

125069-77-4

74352-11-7 structure

74352-11-7

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7488-99-5 structure

7488-99-5

Literature: Helvetica Chimica Acta, , vol. 38, p. 610

124159-69-9 structure

124159-69-9

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7488-99-5 structure

7488-99-5

Literature: Helvetica Chimica Acta, , vol. 44, p. 985 - 993

127-41-3 structure

127-41-3

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7488-99-5 structure

7488-99-5

Literature: Helvetica Chimica Acta, , vol. 44, p. 985 - 993

16910-82-0 structure

16910-82-0

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7488-99-5

Literature: Helvetica Chimica Acta, , vol. 44, p. 985 - 993

26533-79-9 structure

26533-79-9

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7488-99-5 structure

7488-99-5

Literature: Helvetica Chimica Acta, , vol. 44, p. 985 - 993

432-70-2 structure

432-70-2

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7488-99-5 structure

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Literature: Justus Liebigs Annalen der Chemie, , vol. 588, p. 117,123

432-70-2 structure

432-70-2

7553-56-2 structure

7553-56-2

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7488-99-5 structure

7488-99-5

Literature: Justus Liebigs Annalen der Chemie, , vol. 588, p. 117,123

Precursor 7
6060-33-9 74352-11-7 124159-69-9 127-41-3
16910-82-0 432-70-2 7553-56-2
DownStream 1
7235-40-7