114248-23-6

114248-23-6 structure

Name: 2',2'-Difluoro-2'-deoxyuridine
Chemical Name: 2',2'-Difluoro-2'-deoxyuridine
CAS Number: 114248-23-6
Molecular Formula: C₉H₁₀F₂N₂O₅
Molecular Weight: 264.183
Catalog: Biochemical Carbohydrate Monosaccharide
Create Date: 2018-09-21 17:48:49
Modify Date: 2026-06-30 12:59:19
2′,2′-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2′,2′-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro[1].

Name	2',2'-Difluoro-2'-deoxyuridine
Synonyms	Uridine, 2'-deoxy-2',2'-difluoro 1-(2-Deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)-4-hydroxy-2(1H)-pyrimidinone dFdU\|\|\|2',2'-Difluoro-2'-deoxyuridine 2',2'-DIFLUORO-2'-DEOXYURIDINE(Gemcitabine impurity) 1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)pyrimidin- 2,4(1H,3H)-dione (2′-deoxy-2′,2′-difluorouridine) 1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione Uridine,2'-deoxy-2',2'-difluoro 2',2'-Difluorodeoxyuridine 2′,2′-difluorodeoxyuridine 1-((2R,4R,5R)-3,3-difluoro Gemcitabine Impurity C 1-(2-Deoxy-2,2-difluoro-beta-D-erythro-pentofuranosyl)pyrimidin-2,4(1H,3H)-dione (2'-Deoxy-2',2'-difluorouridine) Gemcitabine Metabolite 2',2'-DIFLUORO-2'-DEOXYURIDINE 2'-Deoxy-2',2'-difluoro-D-uridine Gemcitabine impurity C 2'-Deoxy-2',2'-difluorouridine Gemcitabine Dione Impurity 1-[(2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuryl]pyrimidine-2,4(1H,3H)-dione 2'-deoxy-2',2'-difluorouridine 1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione Gemcitabine impurity 6/2',2'-Difluoro-2'-Deoxy Uridine 1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)pyrimidin-2,4(1H,3H)-dione (2′-deoxy-2′,2′-difluorouridine) (β-uridine) 2'-deoxy-2',2'-fluorouracil nucleoside 1-(2-Deoxy-2,2-difluoro-beta-D-erythro-pentofuranosyl)pyrimidin-2,4(1H,3H)-dione (2'-Deoxy-2',2'-dif Uridine Impurity 4 (2',2'-Difluoro-2'-Deoxy Uridine） 2Deoxy-22difluorouridine

Description	2′,2′-Difluorodeoxyuridine (dFdU) is the main metabolite of Gemcitabine (HY-17026). 2′,2′-Difluorodeoxyuridine causes a concentration- and schedule- dependent radiosensitising effect in vitro[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Pauwels B, et al. The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitro. Cancer Chemother Pharmacol. 2006 Aug;58(2):219-28.

Density	1.7±0.1 g/cm3
Melting Point	147-149ºC
Molecular Formula	C₉H₁₀F₂N₂O₅
Molecular Weight	264.183
Exact Mass	264.055786
PSA	104.55000
LogP	-0.53
Index of Refraction	1.587
Storage condition	-20°C Freezer

143157-27-1

~94%

114248-23-6

Literature: ALIOS BIOPHARMA, INC.; Beigelman, Leonid; Wang, Guangyi; Smith, David Bernard; Deval, Jerome; Prhavc, Marija Patent: US2013/165400 A1, 2013 ; Location in patent: Paragraph 0420; 0421 ;

1201895-94-4

~91%

114248-23-6

Literature: Chou; Heath; Patterson; Poteet; Lakin; Hunt Synthesis, 1992 , # 6 p. 565 - 570

122111-03-9

114248-23-6

Literature: US2013/165400 A1, ;

1445381-44-1

114248-23-6

Literature: US2013/165400 A1, ;

103882-84-4

114248-23-6

Literature: Journal of Organic Chemistry, , vol. 53, # 11 p. 2406 - 2409

Precursor 4
143157-27-1 1201895-94-4 122111-03-9 103882-84-4
DownStream 0

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

2877706-21-1	2007120-74-1
2877632-14-7	2877666-66-3
2877642-06-1	2877687-83-5
2877632-37-4	2009115-16-4
2228593-41-5	2877634-84-7