114248-23-6

• 常用中文名：2',2'-二氟-2'-脱氧尿苷
• 常用英文名：2',2'-Difluoro-2'-deoxyuridine
• CAS号：114248-23-6
• 分子式：C₉H₁₀F₂N₂O₅
• 分子量：264.183
• 相关类别： 生物化工 糖类化合物 单糖
• 发布时间：2018-09-21 17:48:49
• 更新时间：2026-06-30 12:59:19
• 2′,2′-Difluorodeoxyuridine (dFdU) 是 Gemcitabine (HY-17026) 的主要代谢物。2′,2′-Difluorodeoxyuridine 在体外引起浓度和时间依赖的放射致敏效应。

名称

• 中文名: 2,2-二氟-2-脱氧尿苷
• 英文名: 2',2'-Difluoro-2'-deoxyuridine
• 中文别名: 吉西他滨代谢物; 脱氨基杂质; 尿苷杂质4(2',2'-二氟-2'-脱氧尿苷); 盐酸吉西他滨杂质C(尿苷杂质6); 吉西他滨杂质C; 2',2'-二氟脱氧尿苷; 吉西他滨杂质03; 2′,2′-Difluorodeoxyuridine (Standd)试剂; Β尿苷; 2',2'-二氟-2'-脱氧尿苷(2',2'-DI-F-DU); 吉西他滨杂质C 脱氨基杂质; 1-((2R,4R,5R)-3,3-二氟-4-羟基-5-(羟甲基)四氢呋喃-2-基)嘧啶-2,4(1H,3H)-二酮; 2'-脱氧-2',2'-二氟尿嘧啶核苷; 2'-脱氧-2',2'-二氟尿苷; 1-[(2R,4R,5R)-3,3-二氟-4-羟基-5-(羟甲基)-2-四氢呋喃基]嘧啶-2,4(1H,3H)-二酮; 2',2'-氟脱氧尿苷
• 英文别名: Uridine, 2'-deoxy-2',2'-difluoro; 1-(2-Deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)-4-hydroxy-2(1H)-pyrimidinone; dFdU|||2',2'-Difluoro-2'-deoxyuridine; 2',2'-DIFLUORO-2'-DEOXYURIDINE(Gemcitabine impurity); 1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)pyrimidin- 2,4(1H,3H)-dione (2′-deoxy-2′,2′-difluorouridine); 1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; Uridine,2'-deoxy-2',2'-difluoro; 2',2'-Difluorodeoxyuridine; 2′,2′-difluorodeoxyuridine; 1-((2R,4R,5R)-3,3-difluoro; Gemcitabine Impurity C; 1-(2-Deoxy-2,2-difluoro-beta-D-erythro-pentofuranosyl)pyrimidin-2,4(1H,3H)-dione (2'-Deoxy-2',2'-difluorouridine); Gemcitabine Metabolite; 2',2'-DIFLUORO-2'-DEOXYURIDINE; 2'-Deoxy-2',2'-difluoro-D-uridine; Gemcitabine impurity C; 2'-Deoxy-2',2'-difluorouridine; Gemcitabine Dione Impurity; 1-[(2R,4R,5R)-3,3-Difluoro-4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuryl]pyrimidine-2,4(1H,3H)-dione; 2'-deoxy-2',2'-difluorouridine; 1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione; Gemcitabine impurity 6/2',2'-Difluoro-2'-Deoxy Uridine; 1-(2-deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)pyrimidin-2,4(1H,3H)-dione (2′-deoxy-2′,2′-difluorouridine) (β-uridine); 2'-deoxy-2',2'-fluorouracil nucleoside; 1-(2-Deoxy-2,2-difluoro-beta-D-erythro-pentofuranosyl)pyrimidin-2,4(1H,3H)-dione (2'-Deoxy-2',2'-dif; Uridine Impurity 4 (2',2'-Difluoro-2'-Deoxy Uridine）; 2Deoxy-22difluorouridine

物化性质

• 密度: 1.7±0.1 g/cm3
• 熔点: 147-149ºC
• 分子式: C₉H₁₀F₂N₂O₅
• 分子量: 264.183
• 精确质量: 264.055786
• PSA: 104.55000
• LogP: -0.53
• 折射率: 1.587
• 储存条件: -20°C Freezer

生物活性

• 描述: 2′,2′-Difluorodeoxyuridine (dFdU) 是 Gemcitabine (HY-17026) 的主要代谢物。2′,2′-Difluorodeoxyuridine 在体外引起浓度和时间依赖的放射致敏效应。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. Pauwels B, et al. The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitro. Cancer Chemother Pharmacol. 2006 Aug;58(2):219-28.

合成路线

143157-27-1 ~94% 114248-23-6

文献：ALIOS BIOPHARMA, INC.; Beigelman, Leonid; Wang, Guangyi; Smith, David Bernard; Deval, Jerome; Prhavc, Marija Patent: US2013/165400 A1, 2013 ; Location in patent: Paragraph 0420; 0421 ;

1201895-94-4 ~91% 114248-23-6

文献：Chou; Heath; Patterson; Poteet; Lakin; Hunt Synthesis, 1992 , # 6 p. 565 - 570

122111-03-9 ~% 114248-23-6

文献：US2013/165400 A1, ;

1445381-44-1 ~% 114248-23-6

文献：US2013/165400 A1, ;

103882-84-4 ~% 114248-23-6

文献：Journal of Organic Chemistry, , vol. 53, # 11 p. 2406 - 2409

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