64118-84-9

64118-84-9 structure

Name: 4'-Hydroxy diclofenac
Chemical Name: 4'-hydroxydiclofenac
CAS Number: 64118-84-9
Molecular Formula: C₁₄H₁₁Cl₂NO₃
Molecular Weight: 312.148
Catalog: analytical chemistry Analytical reagent Ion chromatography reagent
Create Date: 2018-08-06 16:02:23
Modify Date: 2024-01-03 18:28:32
4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties[1][2].

Name	4'-hydroxydiclofenac
Synonyms	4’-Hydroxy Diclofenac 4'-hydroxydiclofenac 4'-Hydroxy Diclofenac Benzeneacetic acid, 2-[(2,6-dichloro-4-hydroxyphenyl)amino]- {2-[(2,6-Dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid

Description	4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
In Vivo	A single oral administration of Diclofenac to humanized mice, the unchanged drug in plasma peaks at 0.25 hour and then declines with a half-life (t1/2) of 2.4 hours. 4'-Hydroxy diclofenac also peaks at 0.25 hour and is undetectable within 24 hours. The plasma concentration of unchanged 4'-Hydroxy diclofenac peaks at 0.25 hour and declines rapidly in Humanized chimeric mice received of 4'-Hydroxy diclofenac (10 mg/kg; a single oral)[2].
References	[1]. J Shimamoto, et al. Lack of Differences in Diclofenac (A Substrate for CYP2C9) Pharmacokinetics in Healthy Volunteers With Respect to the Single CYP2C9*3 Allele. Eur J Clin Pharmacol. 2000 Apr;56(1):65-8. [2]. Hidetaka Kamimura, et al. Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice With Humanized Livers. Drug Metab Dispos. 2015 Mar;43(3):309-16.

Density	1.5±0.1 g/cm3
Boiling Point	432.7±45.0 °C at 760 mmHg
Melting Point	178-185ºC dec.
Molecular Formula	C₁₄H₁₁Cl₂NO₃
Molecular Weight	312.148
Flash Point	215.5±28.7 °C
Exact Mass	311.011597
PSA	69.56000
LogP	4.56
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.690
Storage condition	−20°C
Water Solubility	Soluble in DMSO, ethanol or methanol

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SJRHAT Scandinavian Journal of Rheumatology. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) V.1- 1972- Volume(issue)/page/year: (Suppl 22),5,1978

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H302 + H312 + H332-H319
Precautionary Statements	P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;N: Dangerous for the environment;
Risk Phrases	R25;R37/38;R41;R50/53
Safety Phrases	S26-S39-S45-S60-S61
RIDADR	UN 2811
WGK Germany	3
RTECS	AG6542800
HS Code	2922509090

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%