4'-Hydroxy diclofenac

Modify Date: 2025-08-22 00:20:53

4'-Hydroxy diclofenac structure	Common Name	4'-Hydroxy diclofenac
	CAS Number	64118-84-9	Molecular Weight	312.148
	Density	1.5±0.1 g/cm3	Boiling Point	432.7±45.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₁Cl₂NO₃	Melting Point	178-185ºC dec.
	MSDS	Chinese USA	Flash Point	215.5±28.7 °C
	Symbol	GHS02, GHS07	Signal Word	Danger

Use of 4'-Hydroxy diclofenac

4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties[1][2].

Name	4'-hydroxydiclofenac
Synonym	More Synonyms

Description	4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
In Vivo	A single oral administration of Diclofenac to humanized mice, the unchanged drug in plasma peaks at 0.25 hour and then declines with a half-life (t1/2) of 2.4 hours. 4'-Hydroxy diclofenac also peaks at 0.25 hour and is undetectable within 24 hours. The plasma concentration of unchanged 4'-Hydroxy diclofenac peaks at 0.25 hour and declines rapidly in Humanized chimeric mice received of 4'-Hydroxy diclofenac (10 mg/kg; a single oral)[2].
References	[1]. J Shimamoto, et al. Lack of Differences in Diclofenac (A Substrate for CYP2C9) Pharmacokinetics in Healthy Volunteers With Respect to the Single CYP2C9*3 Allele. Eur J Clin Pharmacol. 2000 Apr;56(1):65-8. [2]. Hidetaka Kamimura, et al. Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice With Humanized Livers. Drug Metab Dispos. 2015 Mar;43(3):309-16.

Density	1.5±0.1 g/cm3
Boiling Point	432.7±45.0 °C at 760 mmHg
Melting Point	178-185ºC dec.
Molecular Formula	C₁₄H₁₁Cl₂NO₃
Molecular Weight	312.148
Flash Point	215.5±28.7 °C
Exact Mass	311.011597
PSA	69.56000
LogP	4.56
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.690
Storage condition	−20°C
Water Solubility	Soluble in DMSO, ethanol or methanol

4'-Hydroxy diclofenac MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AG6542800

CHEMICAL NAME :: Acetic acid, (o-(2,6-dichloro-4-hydroxyanilino)phenyl)-

CAS REGISTRY NUMBER :: 64118-84-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H11-Cl2-N-O3

MOLECULAR WEIGHT :: 312.16

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 190 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SJRHAT Scandinavian Journal of Rheumatology. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) V.1- 1972- Volume(issue)/page/year: (Suppl 22),5,1978

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H302 + H312 + H332-H319
Precautionary Statements	P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T: Toxic;N: Dangerous for the environment;
Risk Phrases	R25;R37/38;R41;R50/53
Safety Phrases	S26-S39-S45-S60-S61
RIDADR	UN 2811
WGK Germany	3
RTECS	AG6542800
HS Code	2922509090

Precursor 9
CAS#:15307-86-5 Diclofenac CAS#:698357-45-8 2-[2-(2',6'-DIC... CAS#:73328-71-9 1-(2,6-DICHLORO... CAS#:15307-79-6 Diclofenac sodium
CAS#:637-62-7 4-Benzoquinone ... CAS#:62300-07-6 2-(2-iodophenyl... CAS#:18698-96-9 2-Iodophenylace... CAS#:6480-66-6 2,6-Dichloro-4-...
CAS#:75117-26-9 N,N-dimethyl-2-...
DownStream 1
CAS#:73328-71-9 1-(2,6-DICHLORO...

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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4’-Hydroxy Diclofenac

4'-hydroxydiclofenac

4'-Hydroxy Diclofenac

Benzeneacetic acid, 2-[(2,6-dichloro-4-hydroxyphenyl)amino]-

{2-[(2,6-Dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid

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China
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Product Name: 4'-Hydroxy diclofenac
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