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2239-64-7

2239-64-7 structure
2239-64-7 structure
  • Name: 6-mercaptopurine-2'-deoxyriboside
  • Chemical Name: 9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purine-6-thione
  • CAS Number: 2239-64-7
  • Molecular Formula: C10H12N4O3S
  • Molecular Weight: 268.29
  • Catalog: Biochemical Nucleoside drugs Deoxynucleotides and their analogues
  • Create Date: 2018-02-14 08:00:00
  • Modify Date: 2024-01-10 12:23:51
  • 2′-Deoxy-6-thioinosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Name 9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purine-6-thione
Synonyms 6-MERCAPTOPURINE-2'-DEOXYRIBONUCLEOSIDE
6-Mercaptopurine-2'-deoxyriboside
6-thio-2'-deoxyinosine
MFCD00056001
6-Mercapto-9-(2'-deoxy-b-D-ribofuranosyl)purine
Description 2′-Deoxy-6-thioinosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Density 1.87g/cm3
Boiling Point 665.9ºC at 760mmHg
Molecular Formula C10H12N4O3S
Molecular Weight 268.29
Flash Point 356.5ºC
Exact Mass 268.06300
PSA 128.28000
LogP 0.12960
Vapour Pressure 1.23E-18mmHg at 25°C
Index of Refraction 1.863
Storage condition −20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UP0762000
CHEMICAL NAME :
9H-Purine-6(1H)-thione, 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-
CAS REGISTRY NUMBER :
2239-64-7
LAST UPDATED :
199206
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H12-N4-O3-S
MOLECULAR WEIGHT :
268.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TDKNAF Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. (Osaka, Japan) V.1-28, 1936-69. For publisher information, see TAKHAA. Volume(issue)/page/year: 27,1,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TDKNAF Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. (Osaka, Japan) V.1-28, 1936-69. For publisher information, see TAKHAA. Volume(issue)/page/year: 27,1,1968
Hazard Codes Xn: Harmful;
Risk Phrases 22
Safety Phrases 36
WGK Germany 3
RTECS UP0762000

Chemsrc provides CAS#:2239-64-7 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 2239-64-7 | Chemsrc address: https://m.chemsrc.com/en/baike/1037816.html

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