6-mercaptopurine-2'-deoxyriboside

Modify Date: 2024-01-10 12:23:51

6-mercaptopurine-2'-deoxyriboside structure	Common Name	6-mercaptopurine-2'-deoxyriboside
	CAS Number	2239-64-7	Molecular Weight	268.29
	Density	1.87g/cm3	Boiling Point	665.9ºC at 760mmHg
	Molecular Formula	C₁₀H₁₂N₄O₃S	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	356.5ºC

Use of 6-mercaptopurine-2'-deoxyriboside

2′-Deoxy-6-thioinosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purine-6-thione
Synonym	More Synonyms

Description	2′-Deoxy-6-thioinosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Density	1.87g/cm3
Boiling Point	665.9ºC at 760mmHg
Molecular Formula	C₁₀H₁₂N₄O₃S
Molecular Weight	268.29
Flash Point	356.5ºC
Exact Mass	268.06300
PSA	128.28000
LogP	0.12960
Vapour Pressure	1.23E-18mmHg at 25°C
Index of Refraction	1.863
Storage condition	−20°C

6-mercaptopurine-2'-deoxyriboside MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UP0762000

CHEMICAL NAME :: 9H-Purine-6(1H)-thione, 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-

CAS REGISTRY NUMBER :: 2239-64-7

LAST UPDATED :: 199206

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H12-N4-O3-S

MOLECULAR WEIGHT :: 268.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TDKNAF Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. (Osaka, Japan) V.1-28, 1936-69. For publisher information, see TAKHAA. Volume(issue)/page/year: 27,1,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TDKNAF Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. (Osaka, Japan) V.1-28, 1936-69. For publisher information, see TAKHAA. Volume(issue)/page/year: 27,1,1968

Hazard Codes	Xn: Harmful;
Risk Phrases	22
Safety Phrases	36
WGK Germany	3
RTECS	UP0762000

Precursor 7
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DownStream 1
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Nucleosides of azathioprine and thiamiprine as antiarthritics.

J. Med. Chem. 32 , 1471-1475, (1989)

Azathioprine [Imuran; 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine] is a widely used immunosuppressive and antiarthritic drug. For the sake of comparison, the riboside, the 2'-deoxyriboside, ...

Synthetic nucleosides and nucleotides. XIV. Facile synthesis and antitumor activities of 6-mercaptopurine 2'-deoxyriboside and related compounds.

J. Pharmacobiodyn. 3 , 105-110, (1980)

Convenient synthesis of oligodeoxynucleotides containing 2'-deoxy-6-thioinosine.

Nucleosides Nucleotides Nucleic Acids 22 , 635-639, (2003)

A facile synthesis of oligodeoxynucleotides (ODN) containing 2'-deoxy-6-thioinosine (dI6S) based on the convertible nucleoside O6-phenyl-2'-deoxyinosine is presented. After standard solid-phase DNA sy...

6-MERCAPTOPURINE-2'-DEOXYRIBONUCLEOSIDE

6-Mercaptopurine-2'-deoxyriboside

6-thio-2'-deoxyinosine

MFCD00056001

6-Mercapto-9-(2'-deoxy-b-D-ribofuranosyl)purine

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Inosine,2'-deoxy-6-thio- (9CI)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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