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890-38-0

890-38-0 structure
890-38-0 structure
  • Name: 2'-Deoxyinosine
  • Chemical Name: 2ʼ-deoxyinosine
  • CAS Number: 890-38-0
  • Molecular Formula: C10H12N4O4
  • Molecular Weight: 252.227
  • Catalog: Biochemical Nucleoside drugs Nucleotides and their analogues
  • Create Date: 2018-09-12 07:10:35
  • Modify Date: 2024-01-02 12:36:49
  • 2’-deoxyadenosine inhibits the growth of human colon-carcinoma cell lines and is found to be associated with purine nucleoside phosphorylase (PNP) deficiency.
Name 2ʼ-deoxyinosine
Synonyms INOSINE, 2'-DEOXY-
Inosine,2'-deoxy
EINECS 212-964-1
9H-Purin-6-ol, 9-(2-deoxy-β-D-erythro-pentofuranosyl)-
2'-Deoxyinosine
9-(2-deoxy-b-D-erythro-pentofuranosyl)-Hypoxanthine
9-(2-deoxy-β-D-erythro-pentofuranosyl)-Hypoxanthine
9-(2-Deoxy-b-D-erythro-pentofuranosyl)-1,9-dihydro-6H-purin-6-one
9-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol
Deoxyinosine
(-)-2'-Deoxyinosine
d-Ino
2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE TRISODIUM SALT,DGTP
MFCD00005762
Description 2’-deoxyadenosine inhibits the growth of human colon-carcinoma cell lines and is found to be associated with purine nucleoside phosphorylase (PNP) deficiency.
Related Catalog
Target

Human Endogenous Metabolite
In Vitro In the absence of deoxycoformycin, 2’-deoxyadenosine is primarily deaminated to 2’-deoxyinosine and then converted into hypoxanthine. In the presence of the inhibitor, the deoxynucleoside, in addition to a phosphorylation process, undergoes phosphorolytic cleavage giving rise to adenine. The conversion of 2’-deoxyadenosine to adenine might represent a protective device, emerging when the activity of adenosine deaminase is reduced or inhibited. There is much evidence to indicate that the enzyme catalyzing this processs may be distinct from methylthioadenosine phosphorylase and S-adenosyl homocysteine hydrolase, which are the enzymes reported to be responsible for the formation of adenine from 28-deoxyadenosine in mammals[1].
Cell Assay Various amounts of cells, ranging from 1,000 to 900,000, suspended in 3 mL of standard medium, are plated in 35-mm dishes and incubated in the absence (control) and in the presence of both 1 μM dCF and 0.1 mM dAdo, as indicated in each experiment. dCf was added to the standard medium 30 min before 2’-deoxyadenosine (dAdo). Furthermore, an incubation is performed in which 0.1 mM 2’-deoxyadenosine alone is added to the standard medium. After 4 days of incubation, the standard medium is withdrawn, then 0.5 mL of 0.025% trypsin containing 0.02% EDTA is added and kept for few minutes at 37°C. The cells are collected, diluted in an appropriate volume of standard medium, and counted[1].
References

[1]. Bemi V, et al. Deoxyadenosine metabolism in a human colon-carcinoma cell line (LoVo) in relation to its cytotoxic effect in combination with deoxycoformycin. Int J Cancer. 1998 Mar 2;75(5):713-20.
Density 1.9±0.1 g/cm3
Boiling Point 620.6±65.0 °C at 760 mmHg
Melting Point 250 °C
Molecular Formula C10H12N4O4
Molecular Weight 252.227
Flash Point 329.1±34.3 °C
Exact Mass 252.085861
PSA 113.26000
LogP -1.43
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.837
Storage condition -20°C
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn,Xi
Risk Phrases R20/21/22
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2934999090
HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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