890-38-0

890-38-0 structure

Name: 2'-Deoxyinosine
Chemical Name: 2ʼ-deoxyinosine
CAS Number: 890-38-0
Molecular Formula: C₁₀H₁₂N₄O₄
Molecular Weight: 252.227
Catalog: Biochemical Nucleoside drugs Nucleotides and their analogues
Create Date: 2018-09-12 07:10:35
Modify Date: 2024-01-02 12:36:49
2’-deoxyadenosine inhibits the growth of human colon-carcinoma cell lines and is found to be associated with purine nucleoside phosphorylase (PNP) deficiency.

Name	2ʼ-deoxyinosine
Synonyms	INOSINE, 2'-DEOXY- Inosine,2'-deoxy EINECS 212-964-1 9H-Purin-6-ol, 9-(2-deoxy-β-D-erythro-pentofuranosyl)- 2'-Deoxyinosine 9-(2-deoxy-b-D-erythro-pentofuranosyl)-Hypoxanthine 9-(2-deoxy-β-D-erythro-pentofuranosyl)-Hypoxanthine 9-(2-Deoxy-b-D-erythro-pentofuranosyl)-1,9-dihydro-6H-purin-6-one 9-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol Deoxyinosine (-)-2'-Deoxyinosine d-Ino 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE TRISODIUM SALT,DGTP MFCD00005762

Description	2’-deoxyadenosine inhibits the growth of human colon-carcinoma cell lines and is found to be associated with purine nucleoside phosphorylase (PNP) deficiency.
Related Catalog	Natural Products >> Saccharides and Glycosides Research Areas >> Cancer Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	In the absence of deoxycoformycin, 2’-deoxyadenosine is primarily deaminated to 2’-deoxyinosine and then converted into hypoxanthine. In the presence of the inhibitor, the deoxynucleoside, in addition to a phosphorylation process, undergoes phosphorolytic cleavage giving rise to adenine. The conversion of 2’-deoxyadenosine to adenine might represent a protective device, emerging when the activity of adenosine deaminase is reduced or inhibited. There is much evidence to indicate that the enzyme catalyzing this processs may be distinct from methylthioadenosine phosphorylase and S-adenosyl homocysteine hydrolase, which are the enzymes reported to be responsible for the formation of adenine from 28-deoxyadenosine in mammals[1].
Cell Assay	Various amounts of cells, ranging from 1,000 to 900,000, suspended in 3 mL of standard medium, are plated in 35-mm dishes and incubated in the absence (control) and in the presence of both 1 μM dCF and 0.1 mM dAdo, as indicated in each experiment. dCf was added to the standard medium 30 min before 2’-deoxyadenosine (dAdo). Furthermore, an incubation is performed in which 0.1 mM 2’-deoxyadenosine alone is added to the standard medium. After 4 days of incubation, the standard medium is withdrawn, then 0.5 mL of 0.025% trypsin containing 0.02% EDTA is added and kept for few minutes at 37°C. The cells are collected, diluted in an appropriate volume of standard medium, and counted[1].
References	[1]. Bemi V, et al. Deoxyadenosine metabolism in a human colon-carcinoma cell line (LoVo) in relation to its cytotoxic effect in combination with deoxycoformycin. Int J Cancer. 1998 Mar 2;75(5):713-20.

Density	1.9±0.1 g/cm3
Boiling Point	620.6±65.0 °C at 760 mmHg
Melting Point	250 °C
Molecular Formula	C₁₀H₁₂N₄O₄
Molecular Weight	252.227
Flash Point	329.1±34.3 °C
Exact Mass	252.085861
PSA	113.26000
LogP	-1.43
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.837
Storage condition	-20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn,Xi
Risk Phrases	R20/21/22
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2934999090

958-09-8

~92%

890-38-0

Literature: Journal of Organic Chemistry, , vol. 60, # 19 p. 6129 - 6134

194287-64-4

~15%

890-38-0

29049-22-7

88899-00-7

Literature: Tetrahedron Letters, , vol. 39, # 40 p. 7397 - 7400

106568-79-0

890-38-0

Literature: Chemical and Pharmaceutical Bulletin, , vol. 44, # 2 p. 288 - 295

1203661-20-4

890-38-0

1203661-23-7

1203661-24-8

Literature: Chemical Research in Toxicology, , vol. 23, # 1 p. 48 - 54

Precursor 3
958-09-8 106568-79-0 1203661-20-4
DownStream 10
106568-79-0 4594-45-0 93778-57-5 91713-46-1
961-07-9 958-09-8 69655-05-6 68-94-0
951-78-0 177779-56-5

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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