101187-40-0
101187-40-0 structure
- Name: PROTAC Linker 15
- Chemical Name: tert-butyl N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]carbamate
- CAS Number: 101187-40-0
- Molecular Formula: C13H28N2O5
- Molecular Weight: 292.37200
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2018-12-25 17:57:45
- Modify Date: 2026-07-16 18:26:14
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PROTAC Linker 15 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 15 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Name | tert-butyl N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]carbamate |
|---|---|
| Synonyms |
Boc-N-Amido-PEG3-Amine
t-Boc-Amido-PEG4-Amine N-Boc-1,11-diamino-3,6,9-trioxaundecane oxalate salt terr-butyl N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]cbamate BOC-N-AMIDO-PEG3-NH2 N-(tert-Butoxycbonyl)-3,6,9-trioxa-1,11-undecanediamine NH2-PEG3-NHBOC N-Boc-2-{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-ethylamine （2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)cbamate 5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethyle t-Boc-N-Amido-PEG3-Amine 11-Trioxa-2-azatridecanoic 13-amino ert-butylN-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]cbamate 13-AMINO-5,8,11-TRIOXA-2-AZATRIDECANOIC ACID TERT-BUTYL ESTER 13-Amino-5,8,11-trioxa-2-azatridecanoic acid 1,1-dimethylethyl ester N-Boc-2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethanamine tert-Butyl (2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)cbamate N-Boc-3,6,9-triox 1-Boc-amino-11-bromo-3.6.9-trioxadecane NHBoc-PEG4-NH2 13-AMINO-5,8,11-TRIOXA-2-AZATRIDECANOIC ACID 1,1-DIMETHYLETHYL ESTER Amino-PEG4-NHBoc [2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]cbamic Acid tert-Butyl Ester tert-butyl N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]cbamate 5,8,11-Trioxa-2-azatridecanoic,13-amino,1,1-dimethylethyl ester t-BocNH-PEG3-CH2CH2NH2 N-Boc-1,11-diamino-3,6,9-trioxaundecane NHBoc-PEG3-amine N-Boc-2-{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy} BocNH-PEG3-CH2CH2NH2/5,8,11-Trioxa-2-azatridecanoic acid, 13-amino-, 1,1-dimethylethyl ester tert-Boc-N-amido-PEG3-amine BOC-NH-PEG3-NH2 1-Boc-amine-11-amino-3,6,9-trioxaundecane 5,8,11-Trioxa-2-azatridecanoic acid, 13-amino-, 1,1-diMethylethyl ester N-Boc-2-{2-[2-(2-amino-ethoxy)-et Boc-NH-PEG3-CH2CH2NH2 |
| Description | PROTAC Linker 15 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 15 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| References |
| Density | 1.05 |
|---|---|
| Molecular Formula | C13H28N2O5 |
| Molecular Weight | 292.37200 |
| Exact Mass | 292.20000 |
| PSA | 92.04000 |
| LogP | 1.61080 |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2924199090 |
|
~97%
101187-40-0 |
| Literature: Tetrahedron, , vol. 68, # 52 p. 10818 - 10826 |
|
~32%
101187-40-0 |
| Literature: WO2005/30258 A2, ; Page/Page column 115 ; WO 2005/030258 A2 |
|
~78%
101187-40-0 |
| Literature: Journal of the American Chemical Society, , vol. 134, # 1 p. 83 - 86 |
|
~26%
101187-40-0 |
| Literature: Journal of Organic Chemistry, , vol. 66, # 11 p. 3709 - 3716 |
|
~98%
101187-40-0 |
| Literature: Tetrahedron Letters, , vol. 39, # 48 p. 8799 - 8802 |
|
~%
101187-40-0 |
| Literature: Journal of the American Chemical Society, , vol. 134, # 1 p. 83 - 86 |
|
~%
101187-40-0 |
| Literature: Journal of the American Chemical Society, , vol. 134, # 1 p. 83 - 86 |
|
~%
101187-40-0 |
| Literature: Journal of the American Chemical Society, , vol. 134, # 1 p. 83 - 86 |
| Precursor 9 | |
|---|---|
| DownStream 1 | |
| HS Code | 2924199090 |
|---|---|
| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |