101187-39-7

101187-39-7 structure

Name: Azido-PEG3-azide
Chemical Name: 1,11-Diazido-3,6,9-trioxaundecane
CAS Number: 101187-39-7
Molecular Formula: C₈H₁₆N₆O₃
Molecular Weight: 244.25100
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-04-01 19:45:54
Modify Date: 2024-01-02 11:59:58
Azido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1,11-Diazido-3,6,9-trioxaundecane
Synonyms	1-azido-2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethane

Description	Azido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport

112-60-7

~88%

101187-39-7

Literature: WO2006/73314 A1, ; Page/Page column 31 ;

37860-51-8

~92%

101187-39-7

Literature: Chemical Communications, , vol. 48, # 45 p. 5650 - 5652

638-56-2

~99%

101187-39-7

Literature: WO2008/11157 A2, ; Page/Page column 174 ;

55400-73-2

~99%

101187-39-7

Literature: Tetrahedron, , vol. 65, # 36 p. 7385 - 7392

112-60-7

~15%

101187-39-7

86770-67-4

Literature: Angewandte Chemie - International Edition, , vol. 51, # 9 p. 2151 - 2154

31255-26-2

~99%

101187-39-7

Literature: Journal of the American Chemical Society, , vol. 127, # 36 p. 12434 - 12435