130-49-4

130-49-4 structure

Name: Adenosine-2'-monophosphate
Chemical Name: adenosine 2'-phosphate
CAS Number: 130-49-4
Molecular Formula: C₁₀H₁₄N₅O₇P
Molecular Weight: 347.221
Catalog: Biochemical Nucleoside drugs Nucleoside intermediate
Create Date: 2018-07-19 12:48:47
Modify Date: 2024-01-04 10:56:06
Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation[1][2].

Name	adenosine 2'-phosphate
Synonyms	Adenosine Monophosphate Hydrate (2'- and 3'- mixture) from Yeast MFCD00151215 Adenosine 2'-monophosphate Adenylic Acid Hydrate (2'- and 3'- mixture) from Yeast Methionyl adenylate adenosine 2'-monophosphoric acid Adenosine 2'(3')-monophosphate mixed isomers Adenosine 2'-phosphate 2'(3')-AMP Hydrate (2'- and 3'- mixture) from Yeast Methioninyl adenylate 2'-Adenylic acid EINECS 204-990-7 L-METHIONYL ADENYLATE 2'-adenosine monophosphate

Description	Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	Human Endogenous Metabolite A2A adenosine receptor A2B adenosine receptor
In Vitro	Adenosine-2'-monophosphate (2'-AMP) (0-100 µM; daily for 4 days) inhibits proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors[1]. Adenosine-2'-monophosphate (30 μM; 24 hours) inhibits LPS induced (100 ng/ml) TNF-α and CXCL10 production in primary murine microglia[1].
References	[1]. Jackson EK, Gillespie DG, Dubey RK. 2'-AMP and 3'-AMP inhibit proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors. J Pharmacol Exp Ther. 2011;337(2):444‐450. [2]. Newell EA, Exo JL, Verrier JD, et al. 2',3'-cAMP, 3'-AMP, 2'-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors. Brain Res. 2015;1594:27‐35.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 60,251,1954

RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AU7480300