Adenosine-2'-monophosphate

Modify Date: 2024-01-04 10:56:06

Adenosine-2'-monophosphate structure	Common Name	Adenosine-2'-monophosphate
	CAS Number	130-49-4	Molecular Weight	347.221
	Density	2.3±0.1 g/cm3	Boiling Point	815.5±75.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₄N₅O₇P	Melting Point	N/A
	MSDS	USA	Flash Point	447.0±37.1 °C

Use of Adenosine-2'-monophosphate

Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation[1][2].

Name	adenosine 2'-phosphate
Synonym	More Synonyms

Description	Adenosine-2'-monophosphate (2'-AMP) is converted by extracellular 2’,3'-CAMP. Adenosine-2'-monophosphate is further metabolized to extracellular adenosine (a mechanism called the extracellular 2’,3’-cAMP-adenosine pathway). Adenosine-2'-monophosphate inhibits LPS-induced TNF-α and CXCL10 production via A2A receptor activation[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	Human Endogenous Metabolite A2A adenosine receptor A2B adenosine receptor
In Vitro	Adenosine-2'-monophosphate (2'-AMP) (0-100 µM; daily for 4 days) inhibits proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors[1]. Adenosine-2'-monophosphate (30 μM; 24 hours) inhibits LPS induced (100 ng/ml) TNF-α and CXCL10 production in primary murine microglia[1].
References	[1]. Jackson EK, Gillespie DG, Dubey RK. 2'-AMP and 3'-AMP inhibit proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors. J Pharmacol Exp Ther. 2011;337(2):444‐450. [2]. Newell EA, Exo JL, Verrier JD, et al. 2',3'-cAMP, 3'-AMP, 2'-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors. Brain Res. 2015;1594:27‐35.

Density	2.3±0.1 g/cm3
Boiling Point	815.5±75.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₄N₅O₇P
Molecular Weight	347.221
Flash Point	447.0±37.1 °C
Exact Mass	347.063080
PSA	195.88000
LogP	-1.74
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.905
Storage condition	−20°C

Adenosine-2'-monophosphate MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7480300

CHEMICAL NAME :: 2'-Adenylic acid

CAS REGISTRY NUMBER :: 130-49-4

BEILSTEIN REFERENCE NO. :: 0058366

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H14-N5-O7-P

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 60,251,1954

RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AU7480300

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Adenosine Monophosphate Hydrate (2'- and 3'- mixture) from Yeast

MFCD00151215

Adenosine 2'-monophosphate

Adenylic Acid Hydrate (2'- and 3'- mixture) from Yeast

Methionyl adenylate

adenosine 2'-monophosphoric acid

Adenosine 2'(3')-monophosphate mixed isomers

Adenosine 2'-phosphate

2'(3')-AMP Hydrate (2'- and 3'- mixture) from Yeast

Methioninyl adenylate

2'-Adenylic acid

EINECS 204-990-7

L-METHIONYL ADENYLATE

2'-adenosine monophosphate

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Product Name: 2'-Adenylic acid
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