122830-14-2

122830-14-2 structure

Name: Deriglidole
Chemical Name: Deriglidole
CAS Number: 122830-14-2
Molecular Formula: C₁₆H₂₁N₃
Molecular Weight: 255.35800
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-07-09 17:57:17
Modify Date: 2024-01-05 08:27:09
Deriglidole is a peripheral adrenoceptor antagonist with a high affinity for α2-adrenoceptors.

Name	Deriglidole
Synonyms	(+)-1,2,4,5-Tetrahydro-2-(2-imidazolin-2-yl)-2-propylpyrrolo(3,2,1-hi)indole UNII-68EP8R4PMV 2-(4,5-dihydro-1h-imidazol-2-yl)-2-propyl-1,2,4,5-tetrahydropyrrolo[3,2,1-hi]indole

Description	Deriglidole is a peripheral adrenoceptor antagonist with a high affinity for α2-adrenoceptors.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Metabolic Disease
Target	Adrenoceptor[1]
In Vitro	Deriglidole is a selective α2-receptor inhibitor. Deriglidole inhibits [3H]Clonidine and [3H]Idazoxan but not [3H]Prazosin binding to rat cortical and human platelet α2-adrenoceptors and is more selective than Idazoxan for peripheral receptors[1].
References	[1]. Natali A, et al. Effects of acute alpha 2-blockade on insulin action and secretion in humans. Am J Physiol. 1998 Jan;274(1 Pt 1):E57-64.