1207384-48-2

1207384-48-2 structure

Name: Nudifloramide-d3
Chemical Name: Nudifloramide-d3
CAS Number: 1207384-48-2
Molecular Formula: C₇H₅D₃N₂O₂
Molecular Weight: 155.16900
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2016-08-07 00:36:57
Modify Date: 2024-01-23 08:11:05
Nudifloramide-d3 (2PY-d3) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro[1].

Name	Nudifloramide-d3
Synonyms	6-oxo-1-(trideuteriomethyl)pyridine-3-carboxamide

Description	Nudifloramide-d3 (2PY-d3) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PARP Research Areas >> Metabolic Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Rutkowski B, et al. N-methyl-2-pyridone-5-carboxamide: a novel uremic toxin? Kidney Int Suppl. 2003 May;(84):S19-21.