Nudifloramide-d3

Modify Date: 2024-01-23 08:11:05

Nudifloramide-d3 Structure
Nudifloramide-d3 structure
Common Name Nudifloramide-d3
CAS Number 1207384-48-2 Molecular Weight 155.16900
Density N/A Boiling Point N/A
Molecular Formula C7H5D3N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Nudifloramide-d3


Nudifloramide-d3 (2PY-d3) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro[1].

 Names

Name Nudifloramide-d3
Synonym More Synonyms

 Nudifloramide-d3 Biological Activity

Description Nudifloramide-d3 (2PY-d3) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro[1].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Rutkowski B, et al. N-methyl-2-pyridone-5-carboxamide: a novel uremic toxin? Kidney Int Suppl. 2003 May;(84):S19-21.

 Chemical & Physical Properties

Molecular Formula C7H5D3N2O2
Molecular Weight 155.16900
Exact Mass 155.07700
PSA 66.08000
LogP 0.36840

 Synonyms

6-oxo-1-(trideuteriomethyl)pyridine-3-carboxamide
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