2208-41-5

2208-41-5 structure
2208-41-5 structure

Name 6-hydroxymelatonin
Synonyms 6-HydroxyMelatonin
6-Hydroxy Melatonin
N-[2-(6-hydroxy-5-methoxy-1H-indol-3-yl)ethyl]acetamide
Description 6-Hydroxymelatonin is a primary metabolic of Melatonin, which is metabolized by cytochrome P450 (CYP) 1A2.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Härtter S, et al. Orally given melatonin may serve as a probe drug for cytochrome P450 1A2 activity in vivo: a pilot study. Clin Pharmacol Ther. 2001 Jul;70(1):10-6.

Density 1.266g/cm3
Boiling Point 564.7ºC at 760mmHg
Melting Point 172-175ºC
Molecular Formula C13H16N2O3
Molecular Weight 248.27800
Flash Point 295.3ºC
Exact Mass 248.11600
PSA 74.35000
LogP 1.95160
Vapour Pressure 2.35E-13mmHg at 25°C
Index of Refraction 1.627
Storage condition Refrigerator
Water Solubility alcohol: soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC3607000
CHEMICAL NAME :
Acetamide, N-(2-(6-hydroxy-5-methoxyindol-3-yl)ethyl)-
CAS REGISTRY NUMBER :
2208-41-5
BEILSTEIN REFERENCE NO. :
0483231
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C13-H16-N2-O3
MOLECULAR WEIGHT :
248.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
8 mg/kg
SEX/DURATION :
male 20 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 33,618,1985
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H302-H351
Precautionary Statements P281
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn: Harmful;
Risk Phrases 22-40
Safety Phrases 36/37
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS AC3607000
HS Code 2933990090
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%