Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Sesamol
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Sesamol
Price: ￥138.0/25g ￥428.0/100g ￥138.0/20mg
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Sesamol
Price: $280.0/20mg
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3,4-(Methylenedioxy)-phenol
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Purity: 98.0%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Sesamol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
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Contact: Anson

533-31-3

533-31-3 structure

533-31-3 structure

Name: Sesamol
Chemical Name: 1,3-benzodioxol-5-ol
CAS Number: 533-31-3
Molecular Formula: C₇H₆O₃
Molecular Weight: 138.121
Catalog: Chemical reagent Organic reagent Phenols
Create Date: 2018-08-26 19:10:11
Modify Date: 2024-01-02 20:20:33
Sesamol is a constituent of sesame oil. Sesamol shows a free radical scavenging activity. Sesamol shows an IC50=5.95±0.56 μg/mL in the DPPH assay. Anti-oxidant activities[1]. Anticancer activities[2].

Name	1,3-benzodioxol-5-ol
Synonyms	5-Benzodioxolol MFCD00005827 5-Hydroxy-1,3-benzodioxole EINECS 208-561-5 Phenol, 3,4- (methylenedioxy)- Sesamol 4,5-methylenedioxyphenol 3,4-Methylenedioxyphenol 1-hydroxy-3,4-methylenedioxybenzene 4-hydroxy-1,2-methylenedioxy-benzene 5-hydroxy-1,3-benzodioxolane 3,4-(Methylenedioxy)phenol Methylene ether of oxyhydroquinone 1,3-benzodioxol-5-ol

Description	Sesamol is a constituent of sesame oil. Sesamol shows a free radical scavenging activity. Sesamol shows an IC50=5.95±0.56 μg/mL in the DPPH assay. Anti-oxidant activities[1]. Anticancer activities[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer Natural Products >> Phenols
In Vitro	Sesamol has also been shown to be a classical inhibitor of lipid peroxidation[1]. Sesamol (0-1 mM) efficiently induces the apoptosis of human liver hepatocellular carcinoma (HepG2) cells. Sesamol suppresses cell proliferation and induces intrinsic and extrinsic apoptosis in HepG2 cells. Sesamol treatment elicites mitochondrial dysfunction by inducing a loss of mitochondrial membrane potential. Sesamol inhibits mitophagy and autophagy through impeding the PI3K Class III/Belin-1 pathway. Sesamol decreases the expression of anti-apoptotic protein Bcl-2, but shows no effect on the expression of apoptotic signal Bax. Sesamol improves the protein expression of Fas/FasL, and activates tBid and caspase-8 which are all involved in the extrinsic apoptosis pathway[2].
In Vivo	Sesamol treatment for 35 days does not significantly impact body weight, although the tumor volume is dramatically inhibited (40.56% size inhibitory rate with Sesamol at 200 mg/kg compared to the control group). However, a lower dose (100 mg/kg Sesamol) only has significant anti-tumor growth effect up to 27 days after the first treatment. The Bcl-2/Bax ratio in tumor tissues is also decreased. Moreover, in the Sesamol treatment group, levels of the cell proliferation marker Ki76 are down-regulated, and levels of the cell apoptosis marker cleaved-caspase 3 are increased when compared to control. The expression of LC3 protein is remarkably decreased by Sesamol in a dose-dependent manner[2]
References	[1]. Kapadia GJ, et al. Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barrvirus early antigen activation assay and the mouse skin two-stage carcinogenesis. Pharmacol Res. 2002 Jun;45(6):499-505. [2]. Liu Z, et al. Sesamol Induces Human Hepatocellular Carcinoma Cells Apoptosis by Impairing MitochondrialFunction and Suppressing Autophagy. Sci Rep. 2017 Apr 4;7:45728.

Density	1.4±0.1 g/cm3
Boiling Point	274.0±29.0 °C at 760 mmHg
Melting Point	62-65 °C(lit.)
Molecular Formula	C₇H₆O₃
Molecular Weight	138.121
Flash Point	119.5±24.3 °C
Exact Mass	138.031693
PSA	38.69000
LogP	1.52
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.609
Storage condition	−20°C
Water Solubility	slightly soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SM0890000

CHEMICAL NAME :: Phenol, 3,4-(methylenedioxy)-

CAS REGISTRY NUMBER :: 533-31-3

BEILSTEIN REFERENCE NO. :: 0127405

LAST UPDATED :: 199709

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C7-H6-O3

MOLECULAR WEIGHT :: 138.13

WISWESSER LINE NOTATION :: T56 BO DO CHJ GQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 874 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

REFERENCE :: JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 83,1279,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1092 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

REFERENCE :: JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 83,1279,1992

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1612 gm/kg/96W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

REFERENCE :: JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 81,207,1990

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1092 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors

REFERENCE :: JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 81,207,1990

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	SM0890000
HS Code	2932999099

Precursor 9
112579-46-1 28281-49-4 120-57-0 80592-18-3
274-09-9 87770-73-8 7228-38-8 17680-04-5
67-56-1
DownStream 10
111726-43-3 94838-82-1 18607-90-4 187040-04-6
21505-19-1 21505-18-0 184041-88-1 187040-02-4
18607-93-7 114899-77-3

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%