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854056-07-8

854056-07-8 structure
854056-07-8 structure
  • Name: (S)-ropivacaine
  • Chemical Name: Ropivacaine mesylate
  • CAS Number: 854056-07-8
  • Molecular Formula: C18H30N2O4S
  • Molecular Weight: 274.401
  • Catalog: API Anesthetic Agents Local anesthetics
  • Create Date: 2018-06-08 22:21:52
  • Modify Date: 2024-01-04 12:55:08
  • Ropivacaine mesylate is an aminoamide compound, effectively blocks neuropathic pain. Ropivacaine mesylate is an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine mesylate inhibits pressure-induces lung endothelial hyperpermeability in models of acute hypertension[1][2].
Name Ropivacaine mesylate
Synonyms (2S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide
(S)-(-)-1-propyl-2',6'-pipecoloxylidide
l-N-n-Propylpipecolic acid-2,6-xylidide
(-)-1-Propyl-2',6'-pipecoloxylidide
UNII-7IO5LYA57N
(-)-1-propyl-2',6'-dimethyl-2-piperidylcarboxyanilide
2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-propyl-, (2S)-
Ropivacaine
Ropivacaine Mesylate API
Ropivacainemesylate
(2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide
(S)-N-(2,6-dimethylphenyl)-1-propyl-2-piperidinecarboxamide
Description Ropivacaine mesylate is an aminoamide compound, effectively blocks neuropathic pain. Ropivacaine mesylate is an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine mesylate inhibits pressure-induces lung endothelial hyperpermeability in models of acute hypertension[1][2].
Related Catalog
In Vivo Epidural administration of Ropivacaine mesylate effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury[1]. Ropivacaine mesylate inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC)[2]. Ropivacaine mesylate prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats[2]. Ropivacaine mesylate inhibits pressure-induced NO production as evidenced by decreased lung nitro-tyrosine content when compared to hypertensive lungs[2]. Animal Model: Adult Sprague-Dawley rats (300–400g)[2] Dosage: 1 μM Administration: Infusion (added to the perfusate reservoir) Result: Attenuated pressure-dependent increases in filtration coefficient (Kf).
References

[1]. Li TF, et al. Epidural sustained release ropivacaine prolongs anti-allodynia and anti-hyperalgesia in developing and established neuropathic pain. PLoS One. 2015 Jan 24;10(1):e0117321.

[2]. Milan Patel, et al. Ropivacaine Inhibits Pressure-Induced Lung Endothelial Hyperpermeability in Models of Acute Hypertension. Life Sci. 2019 Apr 1;222:22-28.
Density 1.0±0.1 g/cm3
Boiling Point 410.2±45.0 °C at 760 mmHg
Molecular Formula C18H30N2O4S
Molecular Weight 274.401
Flash Point 201.9±28.7 °C
Exact Mass 274.204498
PSA 95.09000
LogP 3.11
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.552
HS Code 2942000000
HS Code 2942000000

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title: CAS No. 854056-07-8 | Chemsrc address: https://m.chemsrc.com/en/baike/1101713.html

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