Shanghai Nianxing Industrial Co., Ltd
China
Product Name: L-NMMA acetate
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: L-NMMA acetate
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DC Chemicals Limited
China
Product Name: L-NMMA acetate
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: NG-MONOMETHYL-L-ARGININE ACETATE
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Purity: 98.0%
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53308-83-1

53308-83-1 structure

Name: L-NMMA acetate
Chemical Name: ng-monomethyl-l-arginine acetate
CAS Number: 53308-83-1
Molecular Formula: C₉H₂₀N₄O₄
Molecular Weight: 248.279
Catalog: Biochemical Amino acids and their derivatives Arginine derivatives
Create Date: 2018-03-25 08:00:00
Modify Date: 2024-01-02 17:34:35
L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.

Name	ng-monomethyl-l-arginine acetate
Synonyms	L-NMMA MONOACETATE ANO 1020 NG-Methyl-L-arginine acetate salt H-ARG(ME)-OH ACOH NG-Monomethyl-L-arginine monoacetate NMMA ACETATE SALT Nω-Monomethyl-L-arginine Acetate MFCD00069311 L-NMMA,ACETATE SALT NoMega-MonoMethyl-L-arginine Acetate NG-ME-L-ARG,ACOH NG-Methylarginine acetate Nω-Methyl-L-arginine Acetate L-NMMA ACETATE NMMA L-Ornithine, N-[imino(methylamino)methyl]-, acetate (1:1) N-(N-Methylcarbamimidoyl)-L-ornithine acetate (1:1) L-NMMA Tilarginine acetate

Description	L-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Cardiovascular Disease
Target	Ki: 0.18 µM (nNOS), 0.4 µM (eNOS), 6 µM (iNOS)[1]
In Vitro	L-NMMA, starting from 100 μM, produces a concentration-dependent inhibition of the evoked relaxations (2Hz); maximal inhibition at 1 mM averaged about 35%. The inhibitory effect of L-NMMA is unchanged by previous incubation with D-arginine while it is prevented by L-arginine (L-Arg). L-NMMA does not affect isoprenaline-induced relaxation[2]. Superfusion of L-NMMA reduces arteriolar diameter and causes dose-dependent increases in arteriolar tone. The onset of action of L-NMMA is nearly immediate. L-NMMA inhibits vasodilator responses to the endothelium-dependent vasodilator ACh but not to the endothelium-independent NP. NE induced dose-related vasoconstriction that is significantly potentiated by L-NMMA[3].
Kinase Assay	NOS activity is determined by monitoring the conversion of L-[14C]arginine to [14C]citrulline. For nNOS, reaction mixtures contain, in a final volume of 200 μL, 20 mM Na+ HEPES buffer, pH 7.5, 100 μM EDTA, 2 mM CaCl2, 10 μg/mL calmodulin, 500 μM dithiothreitol, 100 μM THB, 25 μM FAD, 25 μM FMN, 100 μg/mL bovine serum albumin, 20 μM L-[14C]citrulline, 500 PM NADPH, and enzyme. Reaction is initiated by the addition of L-[14C]citrulline; reaction temperature is 25°C. At appropriate times, typically 3.5, 7, and 10.5 min, 50-1.11 portions are removed and added to 200 pl of a stopping solution of 100 mM Na+ HEPES buffer, pH 5.5, containing 5 mM EGTA. Those samples are immediately heated for 1 min in a boiling water bath, chilled, and centrifuged. A portion (225 μL) of the supernatant is fractionated on small Dowex 50 columns. [14C]citrulline is eluted with 2 ml of water and is quantitated by liquid scintillation counting[1].
References	[1]. Frey C, et al. L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases. J Biol Chem. 1994 Oct 21;269(42):26083-91. [2]. Maggi CA, et al. Effect of NG-monomethyl L-arginine (L-NMMA) and NG-nitro L-arginine (L-NOARG) on non-adrenergic non-cholinergic relaxation in the circular muscle of the human ileum. Br J Pharmacol. 1991 Aug;103(4):1970-2. [3]. Nakamura T, et al. Effect of NG-monomethyl-L-arginine on arcade arterioles of rat spinotrapezius muscles. Am J Physiol. 1991 Jul;261(1 Pt 2):H46-52.

Boiling Point	392.7ºC at 760 mmHg
Melting Point	180-190ºC
Molecular Formula	C₉H₂₀N₄O₄
Molecular Weight	248.279
Flash Point	191.3ºC
Exact Mass	248.148453
PSA	148.53000
LogP	0.59500

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	29252900

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