Name | tert-Butyl (6-bromohexyl)carbamate |
---|---|
Synonyms |
tert-butyl N-(6-bromohexyl)carbamate
2-Methyl-2-propanyl (6-bromohexyl)carbamate tert-Butyl (6-bromohexyl)carbamate Carbamic acid, N-(6-bromohexyl)-, 1,1-dimethylethyl ester |
Description | Boc-NH-C6-Br is a cleavable linker used for antibody-drug conjugates (ADC)[1]. |
---|---|
Related Catalog | |
References |
[1]. Jan Anderl, et al. Amatoxin-antibody conjugates. WO2016142049A1. |
Density | 1.2±0.1 g/cm3 |
---|---|
Boiling Point | 340.1±25.0 °C at 760 mmHg |
Molecular Formula | C11H22BrNO2 |
Molecular Weight | 280.202 |
Flash Point | 159.5±23.2 °C |
Exact Mass | 279.083374 |
PSA | 38.33000 |
LogP | 3.63 |
Vapour Pressure | 0.0±0.7 mmHg at 25°C |
Index of Refraction | 1.473 |
Storage condition | 2-8°C |
Symbol |
GHS05 |
---|---|
Signal Word | Danger |
Hazard Statements | H318 |
Precautionary Statements | P280-P305 + P351 + P338 |
Personal Protective Equipment | Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
Hazard Codes | Xi |
Risk Phrases | R41 |
Safety Phrases | 26-39 |
RIDADR | UN 3082 9/PG 3 |
WGK Germany | 3 |
HS Code | 2924199090 |
~93% 142356-33-0 |
Literature: Keller; Haner Helvetica Chimica Acta, 1993 , vol. 76, # 2 p. 884 - 892 |
~% 142356-33-0 |
Literature: US6878715 B1, ; |
~%
Detail
|
Literature: US2002/28823 A1, ; |
~% 142356-33-0 |
Literature: Journal of Medicinal Chemistry, , vol. 37, # 16 p. 2537 - 2551 |
~% 142356-33-0 |
Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 15 p. 4208 - 4212 |
~% 142356-33-0 |
Literature: Journal of the Chemical Society, Perkin Transactions 2, , # 5 p. 923 - 927 |
~% 142356-33-0 |
Literature: Journal of the Chemical Society, Perkin Transactions 2, , # 5 p. 923 - 927 |
~% 142356-33-0 |
Literature: Journal of the Chemical Society, Perkin Transactions 2, , # 5 p. 923 - 927 |
~% 142356-33-0 |
Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 15 p. 4208 - 4212 |
Precursor 9 | |
---|---|
DownStream 1 | |
HS Code | 2924199090 |
---|---|
Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |