93718-83-3
93718-83-3 structure
- Name: NSC 95397
- Chemical Name: 2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione
- CAS Number: 93718-83-3
- Molecular Formula: C14H14O4S2
- Molecular Weight: 310.39
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
- Create Date: 2018-12-30 15:39:33
- Modify Date: 2024-01-29 23:21:25
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NSC 95397 is an inhibitor for dual-specificity phosphatases, including mitogen-activated protein kinase phosphatase-1 (MKP-1). NSC 95397 suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway[1].
| Name | 2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione |
|---|---|
| Synonyms | 2,3-bis(2-hydroxyethylsulfanyl)naphthalene-1,4-dione |
| Description | NSC 95397 is an inhibitor for dual-specificity phosphatases, including mitogen-activated protein kinase phosphatase-1 (MKP-1). NSC 95397 suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway[1]. |
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| Related Catalog | |
| In Vitro | NSC 95397 (0, 10, and 20 µM; 24 hour) decreases the cell viability of three colon cancer cell lines SW480, SW620, and DLD-1 in a concentration-dependent manner[1]. NSC 95397(10 μM; 24 hour) upregulates p21 while downregulates CDK4 and CDK6 were d in all three colon cancer cell lines SW480, SW620, and DLD-1 cells[1]. NSC 95397 (10 μM; 24 hour) reduces the phosphorylation of retinoblastoma protein (Rb) on Ser795 and Ser807/811[1]. NSC 95397 (20 μM; 24 hours) significantly increases cleaved caspase-9, -3, -7 and PARP levels[1]. NSC 95397 (10 μM; 6 hours) enhances the phosphorylation of its downstream ERK1/2 at Thr202/Tyr 204[1]. Cell Viability Assay[1] Cell Line: Human colon cancer cell lines, SW480, SW620, and DLD-1 Concentration: 0, 10, and 20 µM Incubation Time: 24 hours Result: The IC50 values of NSC 95397 for the cell growth of SW480, SW620, and DLD-1 cells were 9.9, 14.1 and 18.6 μM, respectively. Western Blot Analysis[1] Cell Line: SW480, SW620, and DLD-1 cells Concentration: 10 μM Incubation Time: 24 hours Result: p21 was upregulated while CDK4 and CDK6 were downregulated. Rduced the phosphorylation of Rb on Ser795 and Ser807/811 |
| References |
| Density | 1.46g/cm3 |
|---|---|
| Boiling Point | 499.2ºC at 760mmHg |
| Molecular Formula | C14H14O4S2 |
| Molecular Weight | 310.39 |
| Flash Point | 255.7ºC |
| Exact Mass | 310.03300 |
| PSA | 125.20000 |
| LogP | 1.72820 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| HS Code | 2930909090 |
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93718-83-3 |
| Literature: Kulka,M. Canadian Journal of Chemistry, 1962 , vol. 40, p. 1235 - 1241 |
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |