NSC 95397

Modify Date: 2024-01-29 23:21:25

NSC 95397 Structure
NSC 95397 structure
Common Name NSC 95397
CAS Number 93718-83-3 Molecular Weight 310.39
Density 1.46g/cm3 Boiling Point 499.2ºC at 760mmHg
Molecular Formula C14H14O4S2 Melting Point N/A
MSDS USA Flash Point 255.7ºC

 Use of NSC 95397


NSC 95397 is an inhibitor for dual-specificity phosphatases, including mitogen-activated protein kinase phosphatase-1 (MKP-1). NSC 95397 suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway[1].

 Names

Name 2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione
Synonym More Synonyms

 NSC 95397 Biological Activity

Description NSC 95397 is an inhibitor for dual-specificity phosphatases, including mitogen-activated protein kinase phosphatase-1 (MKP-1). NSC 95397 suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway[1].
Related Catalog
In Vitro NSC 95397 (0, 10, and 20 µM; 24 hour) decreases the cell viability of three colon cancer cell lines SW480, SW620, and DLD-1 in a concentration-dependent manner[1]. NSC 95397(10 μM; 24 hour) upregulates p21 while downregulates CDK4 and CDK6 were d in all three colon cancer cell lines SW480, SW620, and DLD-1 cells[1]. NSC 95397 (10 μM; 24 hour) reduces the phosphorylation of retinoblastoma protein (Rb) on Ser795 and Ser807/811[1]. NSC 95397 (20 μM; 24 hours) significantly increases cleaved caspase-9, -3, -7 and PARP levels[1]. NSC 95397 (10 μM; 6 hours) enhances the phosphorylation of its downstream ERK1/2 at Thr202/Tyr 204[1]. Cell Viability Assay[1] Cell Line: Human colon cancer cell lines, SW480, SW620, and DLD-1 Concentration: 0, 10, and 20 µM Incubation Time: 24 hours Result: The IC50 values of NSC 95397 for the cell growth of SW480, SW620, and DLD-1 cells were 9.9, 14.1 and 18.6 μM, respectively. Western Blot Analysis[1] Cell Line: SW480, SW620, and DLD-1 cells Concentration: 10 μM Incubation Time: 24 hours Result: p21 was upregulated while CDK4 and CDK6 were downregulated. Rduced the phosphorylation of Rb on Ser795 and Ser807/811
References

[1]. Dubey NK, et al. NSC 95397 Suppresses Proliferation and Induces Apoptosis in Colon Cancer Cells through MKP-1 and the ERK1/2 Pathway. Int J Mol Sci. 2018 May 31;19(6). pii: E1625.

 Chemical & Physical Properties

Density 1.46g/cm3
Boiling Point 499.2ºC at 760mmHg
Molecular Formula C14H14O4S2
Molecular Weight 310.39
Flash Point 255.7ºC
Exact Mass 310.03300
PSA 125.20000
LogP 1.72820

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
HS Code 2930909090

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles1

More Articles
Characterization of in vivo keratin 19 phosphorylation on tyrosine-391.

PLoS ONE 5 , e13538, (2010)

Keratin polypeptide 19 (K19) is a type I intermediate filament protein that is expressed in stratified and simple-type epithelia. Although K19 is known to be phosphorylated on tyrosine residue(s), con...

 Synonyms

2,3-bis(2-hydroxyethylsulfanyl)naphthalene-1,4-dione
Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: NSC95397
  • Price: $550.0/100mg $950.0/250mg $1800.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

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