NSC 95397 structure
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Common Name | NSC 95397 | ||
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CAS Number | 93718-83-3 | Molecular Weight | 310.39 | |
Density | 1.46g/cm3 | Boiling Point | 499.2ºC at 760mmHg | |
Molecular Formula | C14H14O4S2 | Melting Point | N/A | |
MSDS | USA | Flash Point | 255.7ºC |
Use of NSC 95397NSC 95397 is an inhibitor for dual-specificity phosphatases, including mitogen-activated protein kinase phosphatase-1 (MKP-1). NSC 95397 suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway[1]. |
Name | 2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione |
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Synonym | More Synonyms |
Description | NSC 95397 is an inhibitor for dual-specificity phosphatases, including mitogen-activated protein kinase phosphatase-1 (MKP-1). NSC 95397 suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway[1]. |
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Related Catalog | |
In Vitro | NSC 95397 (0, 10, and 20 µM; 24 hour) decreases the cell viability of three colon cancer cell lines SW480, SW620, and DLD-1 in a concentration-dependent manner[1]. NSC 95397(10 μM; 24 hour) upregulates p21 while downregulates CDK4 and CDK6 were d in all three colon cancer cell lines SW480, SW620, and DLD-1 cells[1]. NSC 95397 (10 μM; 24 hour) reduces the phosphorylation of retinoblastoma protein (Rb) on Ser795 and Ser807/811[1]. NSC 95397 (20 μM; 24 hours) significantly increases cleaved caspase-9, -3, -7 and PARP levels[1]. NSC 95397 (10 μM; 6 hours) enhances the phosphorylation of its downstream ERK1/2 at Thr202/Tyr 204[1]. Cell Viability Assay[1] Cell Line: Human colon cancer cell lines, SW480, SW620, and DLD-1 Concentration: 0, 10, and 20 µM Incubation Time: 24 hours Result: The IC50 values of NSC 95397 for the cell growth of SW480, SW620, and DLD-1 cells were 9.9, 14.1 and 18.6 μM, respectively. Western Blot Analysis[1] Cell Line: SW480, SW620, and DLD-1 cells Concentration: 10 μM Incubation Time: 24 hours Result: p21 was upregulated while CDK4 and CDK6 were downregulated. Rduced the phosphorylation of Rb on Ser795 and Ser807/811 |
References |
Density | 1.46g/cm3 |
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Boiling Point | 499.2ºC at 760mmHg |
Molecular Formula | C14H14O4S2 |
Molecular Weight | 310.39 |
Flash Point | 255.7ºC |
Exact Mass | 310.03300 |
PSA | 125.20000 |
LogP | 1.72820 |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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RIDADR | NONH for all modes of transport |
HS Code | 2930909090 |
~% NSC 95397 CAS#:93718-83-3 |
Literature: Kulka,M. Canadian Journal of Chemistry, 1962 , vol. 40, p. 1235 - 1241 |
Precursor 2 | |
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DownStream 0 |
HS Code | 2930909090 |
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Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Characterization of in vivo keratin 19 phosphorylation on tyrosine-391.
PLoS ONE 5 , e13538, (2010) Keratin polypeptide 19 (K19) is a type I intermediate filament protein that is expressed in stratified and simple-type epithelia. Although K19 is known to be phosphorylated on tyrosine residue(s), con... |
2,3-bis(2-hydroxyethylsulfanyl)naphthalene-1,4-dione |